卡培他滨,临床注释-2,变异和临床注释数据

id	等位基因	注释文本
1278	GG	Both variants of rs17376848 are assigned normal function by CPIC. Patients with the GG genotype and cancer who are treated with capecitabine, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the AG or AA genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.
1277	AG	Both variants of rs17376848 are assigned normal function by CPIC. Patients with the AG genotype and cancer who are treated with capecitabine, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the AA or GG genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.
1276	AA	Both variants of rs17376848 are assigned normal function by CPIC. Patients with the AA genotype and cancer who are treated with capecitabine, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the AG or GG genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.

等位基因

注释文本

Both variants of rs17376848 are assigned normal function by CPIC. Patients with the GG genotype and cancer who are treated with capecitabine, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the AG or AA genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.

1277

Both variants of rs17376848 are assigned normal function by CPIC. Patients with the AG genotype and cancer who are treated with capecitabine, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the AA or GG genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.

1276

Both variants of rs17376848 are assigned normal function by CPIC. Patients with the AA genotype and cancer who are treated with capecitabine, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the AG or GG genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.

id	证据的ID	总结
1598	1449162083	Genotypes AG + GG is not associated with risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colonic Neoplasms as compared to genotype AA.
1597	1448994790	Allele G is not associated with risk of Drug Toxicity when treated with capecitabine in women with Breast Neoplasms as compared to allele A.
1596	1448262714	Allele G is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
1595	1448125175	Genotype AG is associated with increased severity of Stomatitis when treated with capecitabine in people with gastroesophageal cancer as compared to genotype AA.
1594	1448123338	Genotype AG is not associated with likelihood of Drug Toxicity when treated with capecitabine in people with Colorectal Neoplasms as compared to genotype AA.
1593	1448122765	Allele G is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
1592	1447945640	Allele G is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to allele A.
1591	1444698773	Genotype AG is associated with increased severity of Drug Toxicity when exposed to capecitabine, irinotecan and oxaliplatin in people with Colorectal Neoplasms as compared to genotype AA.
1590	769176398	Genotype AG is associated with increased risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms as compared to genotype AA.
1589	PA166109594	Annotation of CPIC Guideline for capecitabine and DPYD

证据的ID

总结

1598

1449162083

Genotypes AG + GG is not associated with risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colonic Neoplasms as compared to genotype AA.

1597

1448994790

Allele G is not associated with risk of Drug Toxicity when treated with capecitabine in women with Breast Neoplasms as compared to allele A.

1596

1448262714

Allele G is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.

1595

1448125175

Genotype AG is associated with increased severity of Stomatitis when treated with capecitabine in people with gastroesophageal cancer as compared to genotype AA.

1594

1448123338

Genotype AG is not associated with likelihood of Drug Toxicity when treated with capecitabine in people with Colorectal Neoplasms as compared to genotype AA.

1593

1448122765

Allele G is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.

1592

1447945640

Allele G is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to allele A.

1591

1444698773

Genotype AG is associated with increased severity of Drug Toxicity when exposed to capecitabine, irinotecan and oxaliplatin in people with Colorectal Neoplasms as compared to genotype AA.

1590

769176398

Genotype AG is associated with increased risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms as compared to genotype AA.

1589

PA166109594

Annotation of CPIC Guideline for capecitabine and DPYD

id	类型	评论
1402	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1401	Update	Added CPIC function and modified text.
1400	Create	Created
1399	Update	evidence for ADR and capecitabine; level 1A due to being part of CPIC guideline (normal function)

类型

1402

Update

CA score added as part of scoring system release. LOE assigned following curator review.

1401

Update

Added CPIC function and modified text.