庆大霉素,临床注释-2,变异和临床注释数据

庆大霉素

临床注释ID

1451436133

药物名称(英)

gentamicin

变异单倍型

rs267606618

基因

MT-RNR1

证据级别

1A

水平覆盖

水平修饰符

Rare Variant; Tier 1 VIP

表现型类别(英)

Toxicity

表现型类别

毒性

分数

101

PMID计数

4

计数的证据

5

表现型

耳毒性

表现型(英)

Ototoxicity

最新日期

2021/6/15 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/1451436133

专业人口(英)

Pediatric

专业人口

儿科

临床等位基因

id	等位基因	注释文本
1260	T	The rs267606618 T allele (also known as the 1095T allele) is assigned as a MT-RNR1 normal risk of aminoglycoside-induced hearing loss allele by CPIC. Patients with the T allele may have a decreased, but not absent, risk of experiencing hearing loss when treated with gentamicin as compared to patients with the C allele. MT-RNR1 is a mitochondrial gene and is inherited as a haploid (i.e. there is only ever one allele present). Other genetic and clinical factors may also influence risk of hearing loss when treated with gentamicin.
1259	C	The rs267606618 C allele (also known as the 1095C allele) is assigned as a MT-RNR1 increased risk of aminoglycoside-induced hearing loss allele by CPIC. Patients with the C allele may have an increased risk of experiencing hearing loss when treated with gentamicin as compared to patients with the T allele. MT-RNR1 is a mitochondrial gene and is inherited as a haploid (i.e. there is only ever one allele present). Other genetic and clinical factors may also influence risk of hearing loss when treated with gentamicin.

临床证据

id	证据的ID	总结
1801	1451438430	Allele C is associated with increased risk of Ototoxicity when treated with aminoglycoside antibacterials, gentamicin, kanamycin or streptomycin.
1800	1444843889	Allele C is associated with increased risk of Ototoxicity when treated with gentamicin, kanamycin or streptomycin as compared to allele T.
1799	1444699702	Allele C is associated with Ototoxicity when treated with gentamicin as compared to allele T.
1798	1444699717	Allele C is associated with Ototoxicity when treated with gentamicin in children as compared to allele T.
1797	PA166229081	Annotation of CPIC Guideline for amikacin, gentamicin, kanamycin, paromomycin, plazomicin, streptomycin, tobramycin and MT-RNR1

临床病史

id	类型	评论
1394	Update	Added CPIC guideline to evidence and edited phenotype descriptions. Awaiting curator check before approval.
1393	Update	Added PMID 21205314 to evidence
1392	Create	Created

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