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临床注释ID
1451666660
药物名称(英)
rosuvastatin
变异单倍型
rs2231142
基因
ABCG2
证据级别
1A
水平覆盖
水平修饰符
Tier 1 VIP
表现型类别(英)
Metabolism/PK
表现型类别
代谢/PK
分数
115.625
PMID计数
11
计数的证据
12
表现型
表现型(英)
最新日期
2022/2/14 0:00:00
URL
https://www.pharmgkb.org/clinicalAnnotation/1451666660
专业人口(英)
专业人口
临床等位基因
id等位基因注释文本
1258 TT The T allele of this variant, when measured on the plus chromosomal strand, is assigned decreased function by CPIC. Patients with the rs2231142 TT genotype may have increased plasma concentrations of rosuvastatin when treated with rosuvastatin as compared to patients with the GG genotype. Other genetic and clinical factors may also influence the metabolism of rosuvastatin. This annotation only covers the pharmacokinetic relationship between rs2231142 and rosuvastatin and does not include evidence about clinical outcomes.
1257 GT The T allele of this variant, when measured on the plus chromosomal strand, is assigned decreased function by CPIC. Patients with the rs2231142 GT genotype may have increased plasma concentrations of rosuvastatin when treated with rosuvastatin as compared to patients with the GG genotype. Other genetic and clinical factors may also influence the metabolism of rosuvastatin. This annotation only covers the pharmacokinetic relationship between rs2231142 and rosuvastatin and does not include evidence about clinical outcomes.
1256 GG The T allele of this variant, when measured on the plus chromosomal strand, is assigned decreased function by CPIC. Patients with the rs2231142 GG genotype may have decreased plasma concentrations of rosuvastatin when treated with rosuvastatin as compared to patients with the TT or GT genotype. Other genetic and clinical factors may also influence the metabolism of rosuvastatin. This annotation only covers the pharmacokinetic relationship between rs2231142 and rosuvastatin and does not include evidence about clinical outcomes.
临床证据
id证据的ID总结
1796 1451141440 Genotypes GT + TT are associated with increased exposure to rosuvastatin in people with Diabetes Mellitus and Hypercholesterolemia as compared to genotype GG.
1795 1451124102 Genotypes GT + TT are associated with increased concentrations of rosuvastatin as compared to genotype GG.
1794 1444693893 Allele T is associated with increased exposure to rosuvastatin in healthy individuals as compared to allele G.
1793 1184169604 Allele T is associated with increased plasma concentrations of rosuvastatin as compared to allele G.
1792 1183631249 Genotype TT is associated with increased plasma concentrations of rosuvastatin when treated with rosuvastatin in people with Hypercholesterolemia as compared to genotype GG.
1791 655388373 Genotype TT is associated with increased AUC of rosuvastatin in people with no disease as compared to genotypes GG + GT.
1790 655388369 Genotype GG is associated with decreased AUC of rosuvastatin in people with no disease as compared to genotypes GT + TT.
1789 1451358668 Genotypes GT + TT are associated with increased exposure to rosuvastatin in healthy individuals as compared to genotype GG.
1788 1451352522 Genotypes GT + TT are associated with increased exposure to rosuvastatin in healthy individuals as compared to genotype GG.
1787 1448612852 Genotype GT is associated with increased exposure to rosuvastatin in healthy individuals as compared to genotype GG.
1786 1451228555 Genotypes GT + TT are associated with increased concentrations of rosuvastatin as compared to genotype GG.
1785 PA166262321 Annotation of CPIC Guideline for rosuvastatin and ABCG2, SLCO1B1
临床病史
id类型评论
1391 Note Second curator check
1390 Update added guideline as evidence
1389 Create Created

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