id	等位基因	注释文本
1255	TT	The T allele of rs3918290 is assigned no function by CPIC. Patients with the TT genotype and cancer who are treated with capecitabine, a fluoropyrimidine-based chemotherapy, may have increased risk and increased severity of drug toxicity as compared to patients with the CC genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.
1254	CT	The T allele of rs3918290 is assigned no function by CPIC. Patients with the CT genotype and cancer who are treated with capecitabine, a fluoropyrimidine-based chemotherapy, may have increased risk and increased severity of drug toxicity as compared to patients with the CC genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.
1253	CC	The T allele of rs3918290 is assigned no function by CPIC. Patients with the CC genotype and cancer who are treated with capecitabine, a fluoropyrimidine-based chemotherapy, may have decreased, but not absent, risk and reduced severity of drug toxicity as compared to patients with the TT or CT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.

id	证据的ID	总结
2403	1449162076	Genotype CT is associated with increased risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colonic Neoplasms as compared to genotype CC.
2402	1448994797	Allele T is associated with increased risk of Drug Toxicity when treated with capecitabine in women with Breast Neoplasms as compared to allele C.
2401	1448124817	Genotype CT is not associated with severity of Drug Toxicity when treated with capecitabine in people with Colorectal Neoplasms as compared to genotype CC.
2400	1448124202	Genotype CT is associated with risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
2399	1447988460	Allele T is associated with risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
2398	1447959056	Allele T is not associated with Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
2397	1450956264	Genotype CT is associated with increased risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to genotype CC.
2396	1450952880	Genotypes CT + TT are associated with increased risk of Drug Toxicity when treated with capecitabine, fluorouracil or tegafur in people with Neoplasms as compared to genotype CC.
2395	1450951600	Genotype CT is associated with increased risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with gastroesophageal cancer.
2394	1450951504	Genotype CT is associated with increased risk of Drug Toxicity when treated with capecitabine in women with Colonic Neoplasms.
2393	1450951460	Genotype TT is associated with increased risk of Drug Toxicity when treated with capecitabine in women with Breast Neoplasms as compared to genotype CC.
2392	1450951410	Genotype CT is associated with increased Drug Toxicity when treated with capecitabine in people with Gastrointestinal Neoplasms as compared to genotype CC.
2391	1450951380	Genotype CT is associated with increased risk of Drug Toxicity when treated with capecitabine in women with Breast Neoplasms as compared to genotype CC.
2390	1184471962	Genotype CT is associated with increased risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms as compared to genotype CC.
2389	1184000475	Allele T is not associated with increased severity of Drug Toxicity when treated with capecitabine in people with Colorectal Neoplasms as compared to allele C.
2388	1183630475	Allele T is associated with increased risk of Drug Toxicity when treated with capecitabine, fluorouracil or tegafur in people with Neoplasms.
2387	769166460	Genotype CT is associated with increased severity of Drug Toxicity when treated with capecitabine in people with Colorectal Neoplasms as compared to genotype CC.
2386	827823452	Genotype CT is not associated with Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
2385	827810882	Genotype CT is associated with increased likelihood of Drug Toxicity when treated with capecitabine in people with Colorectal Neoplasms as compared to genotype CC.
2384	982010242	Genotype CT is associated with increased severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
2383	982006233	Allele T is associated with increased likelihood of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to genotype CC.
2382	981352355	Genotype CT is associated with Death and Drug Toxicity when treated with capecitabine in women with Breast Neoplasms.
2381	981352330	Genotype CT is associated with Death when treated with capecitabine in women with Breast Neoplasms.
2380	1450950682	Genotype CT is associated with increased severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to genotype CC.
2379	769176388	Genotype CT is associated with increased risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms as compared to genotype CC.
2378	PA166104963	Annotation of DPWG Guideline for capecitabine and DPYD
2377	PA166109594	Annotation of CPIC Guideline for capecitabine and DPYD
1784	1450373052	Genotype CT is associated with risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to genotype CC.
1783	1450371900	Genotypes CT + TT are associated with increased risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to genotype CC.
1782	1449732176	Genotype CT is associated with increased risk of Diarrhea when treated with capecitabine or fluorouracil in people with Gastrointestinal Neoplasms.
1781	1449731693	Genotype CT is associated with increased Drug Toxicity when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms as compared to genotype CC.

id	类型	评论
1388	Update	Added DPWG guideline as evidence
1387	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1386	Update	Added rs number to text
1385	Update	Added CPIC function and modified text.
1384	Update	Attached CPIC guideline and removed override.
1383	Create	Created

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