id	等位基因	注释文本
1247	GG	Both variants of rs1801265 are assigned normal function by CPIC. Patients with the GG genotype and cancer who are treated with capecitabine, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the AG or AA genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.
1246	AG	Both variants of rs1801265 are assigned normal function by CPIC. Patients with the AG genotype and cancer who are treated with capecitabine, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the AA or GG genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.
1245	AA	Both variants of rs1801265 are assigned normal function by CPIC. Patients with the AA genotype and cancer who are treated with capecitabine, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the AG or GG genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.

id	证据的ID	总结
2368	1449732144	Genotypes AA + AG is associated with increased risk of Diarrhea when treated with capecitabine or fluorouracil in people with Gastrointestinal Neoplasms as compared to genotype GG.
2367	1449731947	Genotypes AA + AG is associated with decreased Drug Toxicity when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms as compared to genotype GG.
2366	1449162062	Genotypes AG + GG is not associated with risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colonic Neoplasms as compared to genotype AA.
2365	1448262652	Allele G is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
2364	1448125087	Genotypes AG + GG is associated with increased risk of Diarrhea when treated with capecitabine in people with gastroesophageal cancer as compared to genotype AA.
2363	1448125079	Genotypes AG + GG is associated with increased risk of hand-foot syndrome when treated with capecitabine in people with Colorectal Neoplasms as compared to genotype AA.
2362	1448124875	Genotypes AG + GG are not associated with severity of Drug Toxicity when treated with capecitabine in people with Colorectal Neoplasms as compared to genotype AA.
2361	1448124639	Allele G is not associated with increased severity of Drug Toxicity when treated with capecitabine in people with Colorectal Neoplasms as compared to allele A.
2360	1450961080	Genotypes AG + GG are not associated with likelihood of Drug Toxicity when treated with capecitabine in people with Colorectal Neoplasms as compared to genotype AA.
2359	1450954546	Allele G is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to allele A.
2358	1450953284	Allele G is not associated with risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms as compared to allele A.
2357	1448994618	Allele G is associated with decreased risk of Drug Toxicity when treated with capecitabine in women with Breast Neoplasms as compared to allele A.
2356	PA166109594	Annotation of CPIC Guideline for capecitabine and DPYD

id	类型	评论
1379	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1378	Update	Added CPIC function and modified text.
1377	Update	Attached CPIC guideline and removed override.
1376	Create	Created
1375	Update	CA for capecitabine and ADR evidence; level 1A since included in CPIC guideline as normal function variant

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