巯基嘌呤,临床注释-2,变异和临床注释数据

id	等位基因	注释文本
1244	TT	Patients with the rs116855232 TT genotype may have decreased dose of mercaptopurine as compared to patients with the CC genotype. Other genetic and clinical factors may also influence mercaptopurine dose.
1243	CT	Patients with the rs116855232 CT genotype may have decreased dose of mercaptopurine as compared to patients with the CC genotype. Other genetic and clinical factors may also influence mercaptopurine dose.
1242	CC	Patients with the rs116855232 CC genotype may have increased dose of mercaptopurine as compared to patients with the CT or TT genotype. Other genetic and clinical factors may also influence mercaptopurine dose.

等位基因

注释文本

Patients with the rs116855232 TT genotype may have decreased dose of mercaptopurine as compared to patients with the CC genotype. Other genetic and clinical factors may also influence mercaptopurine dose.

1243

Patients with the rs116855232 CT genotype may have decreased dose of mercaptopurine as compared to patients with the CC genotype. Other genetic and clinical factors may also influence mercaptopurine dose.

1242

Patients with the rs116855232 CC genotype may have increased dose of mercaptopurine as compared to patients with the CT or TT genotype. Other genetic and clinical factors may also influence mercaptopurine dose.

id	证据的ID	总结
2355	1449750363	NUDT15 3/3 + 3/5 is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to NUDT15 1/3 + 1/1.
2354	1449750346	NUDT15 1/3 is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to NUDT15 1/1 + 1/5 + 1/6 + 1/2.
2353	1448635204	NUDT15 1/2 is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to NUDT15 1/1.
2352	1448624596	NUDT15 2/3 are associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to NUDT15 1/1.
2351	1448624581	NUDT15 1/2 + 1/3 + 1/5 are associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to NUDT15 1/1.
2350	1448576430	NUDT15 1/2 + 1/3 + 1/4 + 1/6 are associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to NUDT15 1/1.
2349	1447945037	NUDT15 1/1 (assigned as high activity phenotype) is associated with increased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to NUDT15 1/2 + 1/3 + 1/4 + 1/5 + 3/3 + 3/5 + 2/3 (assigned as intermediate and low activity phenotype) .
2348	1449750266	Allele T is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to allele C.
2347	1449749328	Allele T is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to allele C.
2346	1449575844	Genotype TT is associated with decreased dose of azathioprine or mercaptopurine in people with Inflammatory Bowel Diseases as compared to genotypes CC + CT.
2345	1448260651	Genotype CT is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype CC.
2344	1447989974	Genotype CT is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype CC.
2343	1447989193	Genotypes CT + TT is associated with decreased dose of azathioprine or mercaptopurine.
2342	1447682776	Allele T is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to allele C.
2341	1447682735	Genotype CT is associated with decreased dose of azathioprine and mercaptopurine in people with Inflammatory Bowel Diseases as compared to genotype CC.
2340	1447682626	Genotypes CT + TT is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype CC.
2339	1447682392	Genotypes CT + TT is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype CC.
2338	1444703361	Genotype TT is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotypes CC + CT.
2337	PA166104945	Annotation of CPIC Guideline for mercaptopurine and NUDT15, TPMT

证据的ID

总结

2355

1449750363

NUDT15 *3/*3 + *3/*5 is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to NUDT15 *1/*3 + *1/*1.

2354

1449750346

NUDT15 *1/*3 is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to NUDT15 *1/*1 + *1/*5 + *1/*6 + *1/*2.

2353

1448635204

NUDT15 *1/*2 is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to NUDT15 *1/*1.

2352

1448624596

NUDT15 *2/*3 are associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to NUDT15 *1/*1.

2351

1448624581

NUDT15 *1/*2 + *1/*3 + *1/*5 are associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to NUDT15 *1/*1.

2350

1448576430

NUDT15 *1/*2 + *1/*3 + *1/*4 + *1/*6 are associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to NUDT15 *1/*1.

2349

1447945037

NUDT15 *1/*1 (assigned as high activity phenotype) is associated with increased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to NUDT15 *1/*2 + *1/*3 + *1/*4 + *1/*5 + *3/*3 + *3/*5 + *2/*3 (assigned as intermediate and low activity phenotype) .

2348

1449750266

Allele T is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to allele C.

2347

1449749328

Allele T is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to allele C.

2346

1449575844

Genotype TT is associated with decreased dose of azathioprine or mercaptopurine in people with Inflammatory Bowel Diseases as compared to genotypes CC + CT.

2345

1448260651

Genotype CT is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype CC.

2344

1447989974

Genotype CT is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype CC.

2343

1447989193

Genotypes CT + TT is associated with decreased dose of azathioprine or mercaptopurine.

2342

1447682776

Allele T is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to allele C.

2341

1447682735

Genotype CT is associated with decreased dose of azathioprine and mercaptopurine in people with Inflammatory Bowel Diseases as compared to genotype CC.

2340

1447682626

Genotypes CT + TT is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype CC.

2339

1447682392

Genotypes CT + TT is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype CC.

2338

1444703361

Genotype TT is associated with decreased dose of mercaptopurine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotypes CC + CT.

2337

PA166104945

Annotation of CPIC Guideline for mercaptopurine and NUDT15, TPMT

id	类型	评论
1374	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1373	Update	added guideline as evidence, updated text
1372	Create	Created

类型

1374

Update

CA score added as part of scoring system release. LOE assigned following curator review.

1373

Update

added guideline as evidence, updated text

1372

Create

Created