阿米卡星,临床注释-2,变异和临床注释数据

阿米卡星

临床注释ID

1451434920

药物名称(英)

amikacin

变异单倍型

rs267606617

基因

MT-RNR1

证据级别

1A

水平覆盖

水平修饰符

Rare Variant; Tier 1 VIP

表现型类别(英)

Toxicity

表现型类别

毒性

分数

101.25

PMID计数

5

计数的证据

6

表现型

耳毒性

表现型(英)

Ototoxicity

最新日期

2021/6/15 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/1451434920

专业人口(英)

Pediatric

专业人口

儿科

临床等位基因

id	等位基因	注释文本
786	G	The rs267606617 G allele (also known as the 1555G allele) is assigned as a MT-RNR1 increased risk of aminoglycoside-induced hearing loss allele by CPIC. Patients with the G allele may have an increased risk of experiencing hearing loss when treated with amikacin as compared to patients with the A allele. MT-RNR1 is a mitochondrial gene and is inherited as a haploid (i.e. there is only ever one allele present). Other genetic and clinical factors may also influence risk of hearing loss when treated with amikacin.
785	A	The rs267606617 A allele (also known as the 1555A allele) is assigned as a MT-RNR1 normal risk of aminoglycoside-induced hearing loss allele by CPIC. Patients with the A allele may have a decreased, but not absent, risk of experiencing hearing loss when treated with amikacin as compared to patients with the G allele. MT-RNR1 is a mitochondrial gene and is inherited as a haploid (i.e. there is only ever one allele present). Other genetic and clinical factors may also influence risk of hearing loss when treated with amikacin.

临床证据

id	证据的ID	总结
3268	1451436542	Allele G is associated with increased risk of Ototoxicity when treated with amikacin.
3267	1448256010	Allele G is associated with risk of Ototoxicity when treated with amikacin in children with Cystic Fibrosis as compared to allele A.
3266	1444697006	Allele G is associated with Ototoxicity when treated with amikacin, gentamicin, kanamycin, neomycin or streptomycin as compared to allele A.
3265	1444697622	Allele G is associated with Ototoxicity when treated with amikacin, gentamicin or tobramycin in children with Cystic Fibrosis as compared to allele A.
3264	1444697442	Allele G is associated with Ototoxicity when treated with amikacin, gentamicin or streptomycin as compared to allele A.
3263	PA166229081	Annotation of CPIC Guideline for amikacin, gentamicin, kanamycin, paromomycin, plazomicin, streptomycin, tobramycin and MT-RNR1

临床病史

id	类型	评论
1160	Update	Added CPIC guideline to evidence and edited phenotype descriptions. Awaiting curator check before approval.
1159	Update	Added PMID 10661905 to evidence
1158	Create	Created

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