id	等位基因	注释文本
1226	TT	Both variants of rs1801159 are assigned normal function by CPIC. Patients with the TT genotype and cancer who are treated with capecitabine, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the CT or CC genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.
1225	CT	Both variants of rs1801159 are assigned normal function by CPIC. Patients with the CT genotype and cancer who are treated with capecitabine, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the CC or TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.
1224	CC	Both variants of rs1801159 are assigned normal function by CPIC. Patients with the CC genotype and cancer who are treated with capecitabine, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the CT or TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.

id	证据的ID	总结
2730	1449732013	Genotypes CC + CT is not associated with Drug Toxicity when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms as compared to genotype TT.
2729	1449162048	Genotypes CC + CT is not associated with risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colonic Neoplasms as compared to genotype TT.
2728	1448994783	Allele C is not associated with risk of Drug Toxicity when treated with capecitabine in women with Breast Neoplasms as compared to allele T.
2727	1448262704	Allele C is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
2726	1448125094	Genotypes CC + CT are not associated with severity of Drug Toxicity when treated with capecitabine in people with Colorectal Neoplasms or gastroesophageal cancer as compared to genotype TT.
2725	1448124831	Genotypes CC + CT are not associated with severity of Drug Toxicity when treated with capecitabine in people with Colorectal Neoplasms as compared to genotype TT.
2724	1448124670	Allele C is not associated with increased severity of Drug Toxicity when treated with capecitabine in people with Colorectal Neoplasms as compared to allele T.
2723	1448123245	Genotypes CC + CT are not associated with likelihood of Drug Toxicity when treated with capecitabine in people with Colorectal Neoplasms as compared to genotype TT.
2722	1451147880	Allele C is associated with increased risk of Diarrhea due to capecitabine in women with Breast Neoplasms as compared to allele T.
2721	1450954700	Allele C is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to allele T.
2720	1447945633	Allele C is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to allele T.
2719	1447987416	Genotypes CC + CT are not associated with Drug Toxicity when treated with capecitabine, fluorouracil or s 1 (combination) in people with Stomach Neoplasms as compared to genotype TT.
2718	PA166109594	Annotation of CPIC Guideline for capecitabine and DPYD

id	类型	评论
1352	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1351	Update	Attached CPIC guideline and removed override.
1350	Update	Attached CPIC guideline and removed override.
1349	Create	Created
1348	Update	CA for capecitabine and ADR evidence; level 1A since included in CPIC guideline as normal function variant

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