氢可酮,临床注释-2,变异和临床注释数据

id	等位基因	注释文本
1223	*17	The CYP2D617 allele is assigned as a decreased function allele by CPIC. Patients carrying the 17 allele in combination with a decreased or no function allele may have a decreased analgesic response when treated with hydrocodone as compared to patients with alleles that result in a normal metabolizer phenotype, while patients carrying the *17 allele in addition to a normal or increased function allele may have a similar analgesic response when treated with hydrocodone as compared to patients with alleles that result in a normal metabolizer phenotype. Be aware that the CPIC guideline for hydrocodone and CYP2D6 has a 'no recommendation' for CYP2D6 ultrarapid metabolizers. Other genetic and clinical factors may also affect response to hydrocodone.
1222	*5	The CYP2D65 allele is assigned as a no function allele by CPIC. Patients carrying the 5 allele in combination with a decreased, normal or no function allele may have a decreased analgesic response when treated with hydrocodone as compared to patients with alleles that result in a normal metabolizer phenotype, while patients carrying the *5 allele in addition to an increased function allele may have a similar analgesic response when treated with hydrocodone as compared to patients with alleles that result in a normal metabolizer phenotype. Be aware that the CPIC guideline for hydrocodone and CYP2D6 has a 'no recommendation' for CYP2D6 ultrarapid metabolizers. Other genetic and clinical factors may also affect response to hydrocodone.

等位基因

注释文本

The CYP2D6*17 allele is assigned as a decreased function allele by CPIC. Patients carrying the *17 allele in combination with a decreased or no function allele may have a decreased analgesic response when treated with hydrocodone as compared to patients with alleles that result in a normal metabolizer phenotype, while patients carrying the *17 allele in addition to a normal or increased function allele may have a similar analgesic response when treated with hydrocodone as compared to patients with alleles that result in a normal metabolizer phenotype. Be aware that the CPIC guideline for hydrocodone and CYP2D6 has a 'no recommendation' for CYP2D6 ultrarapid metabolizers. Other genetic and clinical factors may also affect response to hydrocodone.

1222

The CYP2D6*5 allele is assigned as a no function allele by CPIC. Patients carrying the *5 allele in combination with a decreased, normal or no function allele may have a decreased analgesic response when treated with hydrocodone as compared to patients with alleles that result in a normal metabolizer phenotype, while patients carrying the *5 allele in addition to an increased function allele may have a similar analgesic response when treated with hydrocodone as compared to patients with alleles that result in a normal metabolizer phenotype. Be aware that the CPIC guideline for hydrocodone and CYP2D6 has a 'no recommendation' for CYP2D6 ultrarapid metabolizers. Other genetic and clinical factors may also affect response to hydrocodone.

id	证据的ID	总结
2717	1451141860	CYP2D6 5/17 is associated with decreased response to hydrocodone or tramadol in women.
2716	1451645100	CYP2D6 poor metabolizers and intermediate metabolizers are associated with decreased response to codeine, fentanyl, hydrocodone, hydromorphone, methadone, morphine, oxycodone or tramadol in people with Neoplasms and Pain as compared to CYP2D6 normal metabolizers.
2715	PA166228121	Annotation of CPIC Guideline for hydrocodone and CYP2D6

证据的ID

总结

2717

1451141860

CYP2D6 *5/*17 is associated with decreased response to hydrocodone or tramadol in women.

2716

1451645100

CYP2D6 poor metabolizers and intermediate metabolizers are associated with decreased response to codeine, fentanyl, hydrocodone, hydromorphone, methadone, morphine, oxycodone or tramadol in people with Neoplasms and Pain as compared to CYP2D6 normal metabolizers.

2715

PA166228121

Annotation of CPIC Guideline for hydrocodone and CYP2D6

id	类型	评论
1347	Update	Added PMID 34423496 to evidence.
1346	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1345	Update	Changed LOE to 1A due to new CPIC opioids guideline. Rewrote phenotype descriptions.
1344	Create	Created

类型

1347

Update

Added PMID 34423496 to evidence.

1346

Update

CA score added as part of scoring system release. LOE assigned following curator review.

1345

Update

Changed LOE to 1A due to new CPIC opioids guideline. Rewrote phenotype descriptions.

1344

Create