华法林,临床注释-2,变异和临床注释数据

华法林

临床注释ID

655385392

药物名称(英)

warfarin

变异单倍型

rs9934438

基因

VKORC1

证据级别

1B

水平覆盖

Yes: Assigned level 1B because variant is not specifically mentioned in clinical guidelines or labels, in high LD with rs9923231

水平修饰符

Tier 1 VIP

表现型类别(英)

Dosage

表现型类别

剂量

分数

109.625

PMID计数

49

计数的证据

52

表现型

表现型(英)

最新日期

2021/11/19 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/655385392

专业人口(英)

Pediatric

专业人口

儿科

临床等位基因

id	等位基因	注释文本
1221	GG	Patients with the rs9934438 GG genotype may require higher dose of warfarin as compared to patients with the AG or AA genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence warfarin dose requirements.
906	AG	Patients with the rs9934438 AG genotype may require a lower dose of warfarin as compared to patients with the GG genotype, and a higher dose as compared to patients with the AA genotype. However, conflicting evidence has been reported. Other clinical and genetic factors may also influence warfarin dose requirements.
905	AA	Patients with the rs9934438 AA genotype may require a lower dose of warfarin as compared to patients with the AG or GG genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence warfarin dose requirements.

临床证据

id	证据的ID	总结
3382	982043353	Genotypes AG + GG are associated with increased warfarin dose when treated with warfarin as compared to genotype AA.
3381	982043330	Genotype AG is associated with increased warfarin dose when treated with warfarin as compared to genotype AA.
3380	982043321	Allele A is associated with decreased warfarin dose when treated with warfarin as compared to allele G.
3379	982038217	Genotypes AG + GG are associated with increased warfarin dose when treated with warfarin as compared to genotype AA.
3378	982035655	Allele A is associated with decreased warfarin dose requirements on day 14 when treated with warfarin as compared to allele G.
3377	982034232	Allele A is associated with decreased dose of warfarin as compared to allele G.
3376	981858915	Genotype GG is associated with increased dose of warfarin in children as compared to genotypes AA + AG.
3375	1451589740	Genotype AA is associated with decreased dose of warfarin as compared to genotypes AC + CC.
2714	827642001	Genotypes AA + AG are associated with decreased dose of warfarin as compared to genotype GG.
2713	1447573633	Allele A is associated with decreased dose of warfarin as compared to allele G.
2712	1447520081	Genotypes AG + GG are not associated with decreased dose of warfarin as compared to genotype AA.
2711	1447519665	Genotypes AA + AG are associated with decreased dose of warfarin as compared to genotype GG.
2710	1446765916	Genotype AA is associated with decreased dose of warfarin as compared to genotypes AG + GG.
2709	1449260063	Allele A is associated with decreased dose of warfarin as compared to allele G.
2708	1449005203	Genotype AA is associated with decreased dose of warfarin as compared to genotypes AG + GG.
2707	1449005156	Genotype AA is associated with decreased dose of warfarin as compared to genotypes AG + GG.
2706	1448601916	Genotype AG is associated with increased dose of warfarin in people with Atrial Fibrillation, Cardiomyopathies, heart valve replacement, Peripheral Vascular Diseases, Pulmonary Embolism and Venous Thrombosis as compared to genotype GG.
2705	1448431482	Genotypes AG + GG are associated with increased dose of warfarin in people with heart valve replacement as compared to genotype AA.
2704	1448276279	Allele A are associated with dose of warfarin in people with Stroke.
2703	1448275994	Genotype GG is associated with increased dose of warfarin as compared to genotype AA.
2702	1448268060	Genotypes AG + GG are associated with increased dose of warfarin in people with Atrial Fibrillation as compared to genotype AA.
2701	1448267977	Genotype AA is associated with decreased dose of warfarin in people with Atrial Fibrillation as compared to genotypes AG + GG.
2700	1448267942	Genotypes AG + GG are associated with increased dose of warfarin in people with Stroke as compared to genotype AA.
2699	1448267909	Genotypes AG + GG are associated with increased dose of warfarin as compared to genotype AA.
2698	1448109658	Allele A is associated with dose of warfarin as compared to allele G.
2697	1451130683	Genotypes AA + AG are associated with decreased dose of warfarin as compared to genotype GG.
2696	982037652	Genotypes AG + GG are associated with increased warfarin dose when treated with warfarin as compared to genotype AA.
2695	1184511615	Genotype AA is associated with decreased dose of warfarin as compared to genotypes AG + GG.
2694	1184510186	Genotype AA is associated with decreased dose of warfarin as compared to genotypes AG + GG.
2693	1184510021	Genotypes AA + AG is associated with decreased dose of warfarin as compared to genotype GG.
2692	1184483630	Genotypes AA + AG is associated with decreased maintenance dose of warfarin when treated with warfarin as compared to genotype GG.
2691	1184472429	Allele A is associated with decreased dose of warfarin as compared to allele G.
2690	1184169091	Genotype AA is associated with decreased dose of warfarin in people with heart valve replacement as compared to genotypes AG + GG.
2689	1183704872	Genotype GG is associated with increased dose of warfarin as compared to genotypes AA + AG.
2688	1183701330	Allele A is associated with decreased dose of warfarin as compared to allele G.
2687	1183699109	Genotype AA is associated with decreased dose of warfarin as compared to genotypes AG + GG.
2686	1183697705	Genotypes AA + AG is associated with decreased dose of warfarin in people with Cardiovascular Diseases as compared to genotype GG.
2685	769277894	Allele A is associated with decreased dose of warfarin as compared to allele G.
2684	637879816	Allele A is associated with decreased dose of warfarin as compared to allele G.
2683	655388076	Allele A is associated with decreased dose of warfarin.
2682	827845768	Genotypes AG + GG are associated with increased dose of warfarin as compared to genotype AA.
2681	827661232	Allele A is associated with decreased dose of warfarin as compared to allele G.
2680	827654491	Genotypes AA + AG are associated with decreased dose of warfarin as compared to genotype GG.
2679	827647045	Allele A is associated with decreased dose of warfarin as compared to allele G.
2678	827642014	Genotypes AA + AG are associated with decreased dose of warfarin as compared to genotype GG.
2677	827567313	Allele A is associated with decreased dose of warfarin as compared to allele G.
2676	982047450	Genotype AA is associated with decreased dose of warfarin in children with Heart Diseases as compared to genotypes AG + GG.
2675	982045909	Allele A is associated with a more rapid attainment of target INR and higher frequency of dose adjustments when treated with warfarin as compared to allele G.
2674	982045891	Allele A is associated with decreased warfarin dose when treated with warfarin as compared to allele G.
2673	982045796	Genotype AG is associated with a lower risk of time to first INR greater than 3.5, but is not a significant factor in influencing the time to reach stable dose in Korean patients with MHVR when treated with warfarin as compared to genotype AA.
2672	982045763	Allele A is associated with decreased warfarin dose in Korean patients with mechanical heart valve replacement since day 7 of warfarin therapy when treated with warfarin as compared to allele G.
2671	982045597	Allele A is associated with decreased warfarin dose when treated with warfarin as compared to allele G.

临床病史

id	类型	评论
1343	Update	Added PMID 31114289 to evidence
1342	Update	Corrected LOE
1341	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1340	Update	updated text
1339	Update	Added PMID 31653973 to evidence
1338	Update	Removed all links to haplotypes.
1337	Update	Reviewed.
1336	Update	Added PMID 27617219

最新招商产品更多>>