id	等位基因	注释文本
904	TT	The T allele of rs3918290 is assigned no function by CPIC. Patients with the TT genotype may have decreased activity of DPYD as compared to patients with the CC genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence catalytic activity of DPYD.
903	CT	The T allele of rs3918290 is assigned no function by CPIC. Patients with the CT genotype may have decreased activity of DPYD as compared to patients with the CC genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence catalytic activity of DPYD.
902	CC	The T allele of rs3918290 is assigned no function by CPIC. Patients with the CC genotype may have increased activity of DPYD as compared to patients with the CT or TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence catalytic activity of DPYD.

id	证据的ID	总结
3374	1449165541	Genotype CT is associated with decreased clearance of fluorouracil in peripheral blood mononuclear cells as compared to genotype CC.
3373	1448605295	Genotype CT is associated with decreased activity of DPYD in peripheral blood mononuclear cells as compared to genotype CC.
3372	1448267629	Allele T is not associated with activity of DPYD.
3371	1447987751	Genotype TT is associated with decreased activity of DPYD when assayed with fluorouracil as compared to genotype CC.
3370	1445400130	Genotype CT is associated with decreased metabolism of fluorouracil in people with Neoplasms as compared to genotype CC.
3369	1450964980	Allele T is associated with decreased activity of DPYD as compared to allele C.
3368	1450960760	Allele T is associated with decreased activity of DPYD as compared to allele C.
3367	1450955720	Genotype CT is associated with decreased activity of DPYD.
3366	1450953420	Genotype CT is associated with decreased activity of DPYD as compared to genotype CC.
3365	1450952584	Genotype CT is not associated with decreased activity of DPYD.
3364	1450951541	Genotype CT is associated with decreased activity of DPYD as compared to genotype CC.
3363	1450951521	Genotype CT is associated with decreased activity of DPYD as compared to genotype CC.
3362	1450951440	Genotype CT is associated with decreased enzyme activity of DPYD as compared to genotype CC.
3361	1450951280	Genotype TT is associated with decreased Purine-Pyrimidine Metabolism, Inborn Errors as compared to genotype CC.
3360	1450950647	Genotype CT is associated with decreased activity of DPYD as compared to genotype CC.
3359	1450950560	Genotype CT is associated with decreased clearance of fluorouracil in people with Colorectal Neoplasms as compared to genotype CC.
3358	1450950160	Genotypes CT + TT are associated with decreased activity of DPYD as compared to genotype CC.
3357	1450950020	Genotype CT is associated with increased likelihood of Purine-Pyrimidine Metabolism, Inborn Errors as compared to genotype CC.
3356	1450949680	Genotype CT is associated with decreased activity of DPYD as compared to genotype CC.
3355	1450945204	Genotype CT is associated with decreased activity of DPYD.
3354	1450945160	Genotype CT is associated with decreased activity of DPYD.
3353	827892647	Genotype CT is associated with decreased clearance of fluorouracil in people with Colorectal Neoplasms as compared to genotype CC.
3352	827827351	Genotype TT is associated with Purine-Pyrimidine Metabolism, Inborn Errors.
3351	827825063	Genotype TT is associated with Purine-Pyrimidine Metabolism, Inborn Errors.
3350	827824632	Genotype CT is associated with decreased metabolism of fluorouracil in people with Neoplasms as compared to genotype CC.
3349	PA166104939	Annotation of DPWG Guideline for fluorouracil and DPYD
3348	PA166122686	Annotation of CPIC Guideline for fluorouracil and DPYD

id	类型	评论
1335	Update	Added DPWG guideline as evidence
1334	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1333	Update	Added conflicting evidence sentence.
1332	Update	Attached CPIC guideline and removed override. Added CPIC function and modified text.
1331	Create	Created

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