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醋硝香豆素
临床注释ID
1184661194
药物名称(英)
acenocoumarol
变异单倍型
rs2108622
基因
CYP4F2
证据级别
2A
水平覆盖
水平修饰符
Tier 1 VIP
表现型类别(英)
Dosage
表现型类别
剂量
分数
11.75
PMID计数
14
计数的证据
15
表现型
心房颤动
表现型(英)
Atrial Fibrillation
最新日期
2021/3/24 0:00:00
URL
https://www.pharmgkb.org/clinicalAnnotation/1184661194
专业人口(英)
专业人口
临床等位基因
id等位基因注释文本
901 TT Patients with the rs2108622 TT genotype who are treated with acenocoumarol may require a higher dose as compared to patients with the CC genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence required acenocoumarol dose.
900 CT Patients with the rs2108622 CT genotype who are treated with acenocoumarol may require a lower dose as compared to patients with the TT genotype or may require a higher dose as compared to patients with the CC genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence required acenocoumarol dose.
899 CC Patients with the rs2108622 CC genotype who are treated with acenocoumarol may require a lower dose as compared to patients with the CT or TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence required acenocoumarol dose.
临床证据
id证据的ID总结
3347 1450186421 Genotypes CT + TT are associated with increased dose of acenocoumarol or warfarin as compared to genotype CC.
3346 1449190771 Allele T is not associated with dose of acenocoumarol or warfarin in people with venous thromboembolism as compared to allele C.
3345 1449188284 Allele T is associated with increased dose of acenocoumarol in people with Atrial Fibrillation as compared to allele C.
3344 1448259328 Allele T is associated with dose of acenocoumarol.
3343 1444708148 Genotypes CT + TT is not associated with dose of acenocoumarol as compared to genotype CC.
3342 1444706936 Allele T is associated with increased dose of acenocoumarol as compared to allele C.
3341 1444705851 Genotypes CT + TT are associated with increased dose of acenocoumarol as compared to genotype CC.
3340 1444699605 Allele T is associated with increased dose of acenocoumarol as compared to allele C.
3339 1184511581 Genotypes CT + TT is associated with increased dose of acenocoumarol as compared to genotype CC.
3338 655388274 Genotype CC is associated with decreased dosage requirement when treated with acenocoumarol in people with Atrial Fibrillation as compared to genotypes CT + TT.
3337 982015210 Genotype TT is not associated with increased dose of acenocoumarol as compared to genotypes CC + CT.
3336 982010017 Genotype TT is associated with increased dose of acenocoumarol as compared to genotype CT.
3335 981954447 Genotype CC is not associated with decreased dose of acenocoumarol as compared to genotypes CT + TT.
3334 981477999 Genotypes CT + TT are associated with 8.3% higher mean daily coumarin dose to reach a stable international normalized ratio (INR) when treated with acenocoumarol, phenprocoumon or warfarin as compared to genotype CC.
3333 982010069 Genotypes CT + TT are not associated with dose of acenocoumarol as compared to genotype CC.
临床病史
id类型评论
1330 Update CA score added as part of scoring system release. LOE assigned following curator review.
1329 Update Added PMID 19270263, 29432897, removed some (PMID 24956252, 24911077 because they were both for TTR (efficacy) and CA is for dose. Also updated to level 2A (was 2B) since it is in a VIP

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