奈韦拉平,临床注释-2,变异和临床注释数据

奈韦拉平

临床注释ID

1449156175

药物名称(英)

nevirapine

变异单倍型

HLA-C*04:01:01:01

基因

HLA-C

证据级别

2B

水平覆盖

水平修饰符

表现型类别(英)

Toxicity

表现型类别

毒性

分数

17

PMID计数

8

计数的证据

9

表现型

嗜酸性粒细胞增多和全身症状的药物反应；表皮坏死松解症，毒性；皮疹；超敏反应；Stevens-Johnson 综合征

表现型(英)

drug reaction with eosinophilia and systemic symptoms;Epidermal Necrolysis, Toxic;Exanthema;Hypersensitivity;Stevens-Johnson Syndrome

最新日期

2021/3/24 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/1449156175

专业人口(英)

专业人口

临床等位基因

id	等位基因	注释文本
889	*04:01:01:01	Patients with one or two copies of the HLA-C04:01:01:01 allele may have an increased risk of experiencing drug hypersensitivity, including cutaneous adverse reactions, when treated with nevirapine as compared to patients with no HLA-C04:01:01:01 alleles or who are negative for the HLA-C*04:01:01:01 test. However, conflicting evidence has been reported. Other genetic and clinical factors may also affect risk of nevirapine-induced hypersensitivity.

临床证据

id	证据的ID	总结
3738	1185002071	HLA-C *04:01:01:01 is associated with increased risk of Drug Toxicity when treated with nevirapine in people with HIV.
3737	1185001907	HLA-C *04:01:01:01 is associated with increased risk of Exanthema when treated with nevirapine in people with HIV.
3736	1184482759	HLA-C *04:01:01:01 is associated with increased risk of Drug Hypersensitivity when treated with nevirapine in people with HIV.
3735	1184407551	HLA-C *04:01:01:01 is not associated with risk of Exanthema when treated with nevirapine in people with HIV.
3298	1448925862	HLA-C *04:01:01:01 is associated with dress syndrome, Epidermal Necrolysis, Toxic or Stevens-Johnson Syndrome when treated with nevirapine in people with HIV.
3297	1444697789	HLA-C *04:01:01:01 is associated with increased risk of Hypersensitivity when treated with nevirapine.
3296	1185002850	HLA-C *04:01:01:01 is associated with increased risk of Drug Hypersensitivity when treated with nevirapine in people with HIV.
3295	1185002808	HLA-C *04:01:01:01 is associated with increased risk of Epidermal Necrolysis, Toxic or Stevens-Johnson Syndrome when treated with nevirapine in people with HIV.
3294	1185002228	HLA-C *04:01:01:01 is associated with increased risk of Drug Hypersensitivity when treated with nevirapine in people with HIV.

临床病史

id	类型	评论
1319	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1318	Update	updated text
1317	Update	Reviewed.
1316	Create

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