瑞舒伐他汀,临床注释-2,变异和临床注释数据

id	等位基因	注释文本
888	TT	Patients with the rs4149056 TT genotype may have decreased risk of statin-related myopathy or myalgia when treated with rosuvastatin as compared to patients with genotype CT or CC. However, conflicting evidence has been reported. Other genetic and clinical factors may also affect risk to rosuvastatin.
887	CT	Patients with the rs4149056 CT genotype may have increased risk of statin-related myopathy or myalgia when treated with rosuvastatin as compared to patients with genotype TT. However, conflicting evidence has been reported. Other genetic and clinical factors may also affect risk to rosuvastatin.
886	CC	Patients with the rs4149056 CC genotype may have increased risk of statin-related myopathy or myalgia when treated with rosuvastatin as compared to patients with genotype TT. However, conflicting evidence has been reported. Other genetic and clinical factors may also affect risk to rosuvastatin.

等位基因

注释文本

Patients with the rs4149056 TT genotype may have decreased risk of statin-related myopathy or myalgia when treated with rosuvastatin as compared to patients with genotype CT or CC. However, conflicting evidence has been reported. Other genetic and clinical factors may also affect risk to rosuvastatin.

887

Patients with the rs4149056 CT genotype may have increased risk of statin-related myopathy or myalgia when treated with rosuvastatin as compared to patients with genotype TT. However, conflicting evidence has been reported. Other genetic and clinical factors may also affect risk to rosuvastatin.

886

Patients with the rs4149056 CC genotype may have increased risk of statin-related myopathy or myalgia when treated with rosuvastatin as compared to patients with genotype TT. However, conflicting evidence has been reported. Other genetic and clinical factors may also affect risk to rosuvastatin.

id	证据的ID	总结
3734	1448821127	Allele C is associated with increased likelihood of statin-related myopathy when treated with rosuvastatin in people with Coronary Artery Disease as compared to allele T.
3733	1448613086	Allele C is not associated with increased risk of Muscular Diseases when treated with atorvastatin, fluvastatin, hmg coa reductase inhibitors, pitavastatin, pravastatin, rosuvastatin or simvastatin as compared to allele T.
3732	1183689645	Allele C is associated with all statin-induced myopathy and severe myopathy when treated with atorvastatin, fluvastatin, hmg coa reductase inhibitors, pravastatin, rosuvastatin or simvastatin as compared to allele T.
3731	1183689628	Genotypes CC + CT is not associated with increased risk of Myalgia unspecified when treated with rosuvastatin as compared to genotype TT.
3730	1450397924	Genotypes CC + CT are associated with increased risk of Muscular Diseases when treated with cerivastatin, hmg coa reductase inhibitors, rosuvastatin or simvastatin as compared to genotype TT.
3729	1451356526	Genotypes CC + CT are not associated with increased risk of Muscular Diseases when treated with rosuvastatin in people with Hyperlipoproteinemia Type II as compared to genotype TT.
3728	1451228540	Genotypes CC + CT are associated with increased risk of Muscular Diseases when treated with rosuvastatin in people with Coronary Artery Disease as compared to genotype TT.
3727	1451226140	Genotype TT is not associated with increased likelihood of Muscular Diseases when treated with atorvastatin or rosuvastatin in people with Diabetes Mellitus, Hyperlipidemias, Hypertension or Obesity as compared to genotypes CC + CT.
3726	PA166262321	Annotation of CPIC Guideline for rosuvastatin and ABCG2, SLCO1B1

证据的ID

总结

3734

1448821127

Allele C is associated with increased likelihood of statin-related myopathy when treated with rosuvastatin in people with Coronary Artery Disease as compared to allele T.

3733

1448613086

Allele C is not associated with increased risk of Muscular Diseases when treated with atorvastatin, fluvastatin, hmg coa reductase inhibitors, pitavastatin, pravastatin, rosuvastatin or simvastatin as compared to allele T.

3732

1183689645

Allele C is associated with all statin-induced myopathy and severe myopathy when treated with atorvastatin, fluvastatin, hmg coa reductase inhibitors, pravastatin, rosuvastatin or simvastatin as compared to allele T.

3731

1183689628

Genotypes CC + CT is not associated with increased risk of Myalgia unspecified when treated with rosuvastatin as compared to genotype TT.

3730

1450397924

Genotypes CC + CT are associated with increased risk of Muscular Diseases when treated with cerivastatin, hmg coa reductase inhibitors, rosuvastatin or simvastatin as compared to genotype TT.

3729

1451356526

Genotypes CC + CT are not associated with increased risk of Muscular Diseases when treated with rosuvastatin in people with Hyperlipoproteinemia Type II as compared to genotype TT.

3728

1451228540

Genotypes CC + CT are associated with increased risk of Muscular Diseases when treated with rosuvastatin in people with Coronary Artery Disease as compared to genotype TT.

3727

1451226140

Genotype TT is not associated with increased likelihood of Muscular Diseases when treated with atorvastatin or rosuvastatin in people with Diabetes Mellitus, Hyperlipidemias, Hypertension or Obesity as compared to genotypes CC + CT.

3726

PA166262321

Annotation of CPIC Guideline for rosuvastatin and ABCG2, SLCO1B1

id	类型	评论
1315	Update	added guideline as evidence
1314	Update	CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
1313	Create	Created

类型

1315

Update

added guideline as evidence

1314

Update

CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.

1313

Create

Created