多虑平,临床注释-2,变异和临床注释数据

多虑平

临床注释ID

1183617854

药物名称(英)

doxepin

变异单倍型

CYP2C19*1, CYP2C19*2

基因

CYP2C19

证据级别

1A

水平覆盖

水平修饰符

Tier 1 VIP

表现型类别(英)

Metabolism/PK

表现型类别

代谢/PK

分数

102

PMID计数

1

计数的证据

2

表现型

表现型(英)

最新日期

2021/3/24 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/1183617854

专业人口(英)

专业人口

临床等位基因

id	等位基因	注释文本
881	*2	The CYP2C192 allele is assigned as a no function allele by CPIC. Patients carrying the CYP2C192 allele in combination with a no, decreased, normal, or increased function allele may have decreased metabolism of doxepin as compared to patients with two normal function alleles. This annotation only covers the pharmacokinetic relationship between CYP2C19 and doxepin and does not include evidence about clinical outcomes. Other genetic and clinical factors may also influence doxepin metabolism.
880	*1	The CYP2C191 allele is assigned as a normal function allele by CPIC. Patients carrying the CYP2C191 allele in combination with another normal function allele may have increased metabolism of doxepin as compared to patients with a no or decreased function allele in combination with a normal or increased function allele or with two no or decreased function alleles. This annotation only covers the pharmacokinetic relationship between CYP2C19 and doxepin and does not include evidence about clinical outcomes. Other genetic and clinical factors may also influence doxepin metabolism.

临床证据

id	证据的ID	总结
3714	1446905865	CYP2C19 2/2 is associated with decreased clearance of doxepin in healthy individuals as compared to CYP2C19 1/1.
3713	PA166105000	Annotation of CPIC Guideline for doxepin and CYP2C19, CYP2D6

临床病史

id	类型	评论
1307	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1306	Update	changed to star allele; LOE changed to 1A because of CPIC guideline
1305	Update	Updated OMB race to appropriate biogeographical group

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