id	等位基因	注释文本
856	TT	Patients with the rs118192177 TT genotype may develop malignant hyperthermia when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with the CC genotype. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.
855	GG	Patients with the rs118192177 GG genotype may develop malignant hyperthermia when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with the CC genotype. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.
854	CT	Patients with the rs118192177 CT genotype may develop malignant hyperthermia when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with the CC genotype. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.
853	CG	Patients with the rs118192177 CG genotype may develop malignant hyperthermia when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with the CC genotype. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.
852	CC	Patients with the rs118192177 CC genotype may have a decreased, but not absent, risk for malignant hyperthermia based on this variant when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with the TT, CT, CG, or GG genotype. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.

id	证据的ID	总结
171	1449160096	Allele T is associated with increased risk of Death and Malignant Hyperthermia when exposed to succinylcholine and volatile anesthetics as compared to allele C.
170	1447987507	Allele T is associated with increased risk of Malignant Hyperthermia as compared to allele C.
169	1447960985	Allele T is associated with increased risk of Malignant Hyperthermia as compared to allele C.
168	1447960682	Allele T is associated with increased risk of Malignant Hyperthermia as compared to allele C.
167	1447952512	Genotype CT is associated with increased risk of Malignant Hyperthermia as compared to genotype CC.
166	1447948638	Genotype CG is associated with increased risk of Malignant Hyperthermia when exposed to succinylcholine and volatile anesthetics as compared to genotype CC.
165	1447675422	Genotype CT is associated with increased risk of Malignant Hyperthermia, Myopathy, Central Core and Rhabdomyolysis as compared to genotype CC.
164	1447674570	Genotype CT is associated with increased risk of Malignant Hyperthermia when exposed to isoflurane and succinylcholine as compared to genotype CC.
163	1447674371	Genotype CT is associated with increased risk of Malignant Hyperthermia as compared to genotype CC.
162	1447674246	Genotype CT is associated with increased risk of Malignant Hyperthermia as compared to genotype CC.
161	1447674091	Allele T is associated with increased risk of Malignant Hyperthermia as compared to allele C.
160	1447673851	Genotype CT is associated with increased risk of Malignant Hyperthermia as compared to genotype CC.
159	1447673805	Genotype CG is associated with increased risk of Malignant Hyperthermia when exposed to halothane and succinylcholine as compared to genotype CC.
158	1447672579	Allele T is associated with increased risk of Malignant Hyperthermia as compared to allele C.
157	1447672498	Allele T is associated with Malignant Hyperthermia as compared to allele C.
156	1447672437	Genotype CT is associated with Malignant Hyperthermia as compared to genotype CC.
155	1447644820	Allele T is associated with increased risk of Malignant Hyperthermia as compared to allele C.
154	1447634887	Allele T is associated with Malignant Hyperthermia as compared to allele C.
153	1447521869	Allele T is associated with Malignant Hyperthermia and multi-core congenital myopathy as compared to allele C.
152	1445400684	Allele T is associated with increased risk of Malignant Hyperthermia as compared to allele C.
151	1444698000	Allele T is associated with increased risk of Malignant Hyperthermia as compared to allele C.
150	1444697837	Allele T is associated with increased risk of Malignant Hyperthermia as compared to allele C.
149	1184510583	Allele T is associated with increased risk of Malignant Hyperthermia when exposed to desflurane, enflurane, halothane, isoflurane, sevoflurane or succinylcholine as compared to allele C.
148	1447674808	Genotype CT is associated with sensitivity to caffeine or halothane in muscle.
147	PA166180457	Annotation of CPIC Guideline for desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane, succinylcholine and CACNA1S, RYR1

id	类型	评论
1277	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1276	Update	Drugs kept combined based on specifics of Malignant Hyperthermia diagnostics and CPIC guideline/EMHG inclusion.
1275	Update	Assigned LOE 1A since variant listed in recommendation of CPIC guideline
1274	Update	Added PMID 25268394

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