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当前位置:药药网 / 数据中心 / 临床注释-2,变异和临床注释数据
醋硝香豆素
临床注释ID
981204044
药物名称(英)
acenocoumarol
变异单倍型
rs9923231
基因
VKORC1
证据级别
1A
水平覆盖
水平修饰符
Tier 1 VIP
表现型类别(英)
Dosage
表现型类别
剂量
分数
147.75
PMID计数
20
计数的证据
25
表现型
表现型(英)
最新日期
2021/3/24 0:00:00
URL
https://www.pharmgkb.org/clinicalAnnotation/981204044
专业人口(英)
专业人口
临床等位基因
id
等位基因
注释文本
837
TT
Patients with the rs9923231 TT genotype may require a decreased dose as of acenocoumarol compared to patients with the CC genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence acenocoumarol dose requirements.
836
CT
Patients with the rs9923231 CT genotype may require a decreased dose of acenocoumarol as compared to patients with the CC genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence acenocoumarol dose requirements.
835
CC
Patients with the rs9923231 CC genotype may require an increased dose of acenocoumarol as compared to patients with the TT and CT genotypes. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence acenocoumarol dose requirements.
临床证据
id
证据的ID
总结
115
1448259376
Genotype CC is associated with increased dose of acenocoumarol in people with Atrial Fibrillation or venous thromboembolism as compared to genotypes CT + TT.
114
1448259324
Allele T is associated with dose of acenocoumarol.
113
1448259259
Allele T is associated with dose of acenocoumarol or phenprocoumon.
112
1448255537
Genotypes CT + TT are associated with decreased dose of acenocoumarol in people with Rheumatic Heart Disease as compared to genotype CC.
111
1184511557
Genotypes CT + TT is associated with decreased dose of acenocoumarol as compared to genotype CC.
110
1183680104
Genotype TT is associated with decreased acenocoumarol dose when treated with acenocoumarol in people with Atrial Fibrillation as compared to genotype CC.
109
827814729
Allele T is associated with decreased dose of acenocoumarol as compared to allele C.
108
982031298
Genotype TT is associated with decreased dose of acenocoumarol as compared to genotype CC.
107
982031288
Genotype CT is associated with decreased dose of acenocoumarol as compared to genotype CC.
106
982015093
Genotype TT is associated with decreased dose of acenocoumarol as compared to genotypes CC + CT.
105
982010039
Genotype CC is associated with increased dose of acenocoumarol as compared to genotype CT.
104
982010028
Genotype TT is not associated with dose of acenocoumarol as compared to genotype CT.
103
982006735
Genotype CT is associated with decreased dose of acenocoumarol as compared to genotype CC.
102
982006724
Genotype TT is associated with decreased dose of acenocoumarol as compared to genotypes CC + CT.
101
981954427
Genotype CC is associated with increased dose of acenocoumarol as compared to genotypes CT + TT.
100
981940056
Genotype CC is associated with increased dose of acenocoumarol as compared to genotypes CT + TT.
99
981859299
Genotype TT is associated with decreased dose of acenocoumarol as compared to genotype CC.
98
981502435
Genotypes CC + CT are associated with increased dose of acenocoumarol or warfarin as compared to genotype TT.
97
1444707179
Genotypes CT + TT are associated with decreased dose of acenocoumarol as compared to genotype CC.
96
1444706967
Genotype TT are associated with decreased dose of acenocoumarol as compared to genotype CC.
95
1444705842
Genotypes CT + TT are associated with decreased dose of acenocoumarol as compared to genotype CC.
94
1444705565
Allele T is associated with decreased dose of acenocoumarol as compared to allele C.
93
1444699595
Allele T is associated with decreased dose of acenocoumarol as compared to allele C.
92
1184754659
Allele T is associated with decreased dose of acenocoumarol as compared to allele C.
91
PA166104938
Annotation of DPWG Guideline for acenocoumarol and VKORC1
临床病史
id
类型
评论
1255
Update
CA score added as part of scoring system release. LOE assigned following curator review.
1254
Update
Adjusted wording to be same framework as warfarin CA.
1253
Update
Attached DPWG guideline. Removed override. Added conflicting evidence statement.
1252
Update
Reviewed.
1251
Update
Checked - does not need update.
1250
Create
Created
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