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氢氯噻嗪
临床注释ID
981202714
药物名称(英)
hydrochlorothiazide
变异单倍型
rs4961
基因
ADD1
证据级别
2B
水平覆盖
水平修饰符
表现型类别(英)
Efficacy
表现型类别
功效
分数
12
PMID计数
8
计数的证据
8
表现型
原发性高血压；高血压
表现型(英)
Essential hypertension;Hypertension
最新日期
2021/3/24 0:00:00
URL
https://www.pharmgkb.org/clinicalAnnotation/981202714
专业人口(英)
专业人口
临床等位基因
id等位基因注释文本
834 TT Patients with the rs4961 TT genotype may have increased response to hydrochlorothiazide treatment as compared to patients with the GG genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence response to hydrochlorothiazide.
833 GT Patients with the rs4961 GT genotype may have increased response to hydrochlorothiazide treatment as compared to patients with the GG genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence response to hydrochlorothiazide.
832 GG Patients with the rs4961 GG genotype may have decreased response to hydrochlorothiazide treatment as compared to patients with the TT or GT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence response to hydrochlorothiazide.
临床证据
id证据的ID总结
534 827924535 Allele T is associated with decreased reduction in ambulatory SBP when treated with hydrochlorothiazide in men with Hypertension as compared to allele G.
533 827923924 Genotypes GT + TT are associated with increased reduction in mean blood pressure when treated with hydrochlorothiazide in people with Hypertension as compared to genotype GG.
532 827923903 Genotypes GT + TT are associated with increased reduction in mean blood pressure when treated with hydrochlorothiazide in people with Hypertension as compared to genotype GG.
531 827923882 Genotype GT is associated with increased reduction in mean arterial pressure when treated with hydrochlorothiazide in people with Essential hypertension as compared to genotype GG.
530 827921263 Allele T is not associated with response to hydrochlorothiazide in people with Essential hypertension as compared to allele G.
529 1451341865 Genotypes GT + TT is associated with increased response to hydrochlorothiazide as compared to genotype GG.
528 769170910 Allele T is associated with decreased absolute mean blood pressure when treated with hydrochlorothiazide in people with Hypertension as compared to genotype GG.
90 827924748 Genotypes GT + TT are associated with increased reduction in blood pressure when treated with hydrochlorothiazide in people with Hypertension as compared to genotype GG.
临床病史
id类型评论
1249 Update CA score added as part of scoring system release. LOE assigned following curator review.
1248 Update Minor edits to phenotype descriptions
1247 Update Fixed format and indicated conflicting study.

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