氟伐他汀,临床注释-2,变异和临床注释数据

氟伐他汀

临床注释ID

1451244700

药物名称(英)

fluvastatin

变异单倍型

rs4149056

基因

SLCO1B1

证据级别

1A

水平覆盖

水平修饰符

Tier 1 VIP

表现型类别(英)

Metabolism/PK

表现型类别

代谢/PK

分数

101.875

PMID计数

2

计数的证据

3

表现型

表现型(英)

最新日期

2022/2/10 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/1451244700

专业人口(英)

专业人口

临床等位基因

id	等位基因	注释文本
720	TT	Patients with the rs4149056 TT genotype may have decreased concentrations of fluvastatin as compared to patients with the CC or CT genotypes. However, conflicting evidence has been reported. Other genetic and clinical factors may also affect fluvastatin concentrations. This annotation only covers the pharmacokinetic relationship between rs4149056 and fluvastatin and does not include evidence about clinical outcomes.
719	CT	Patients with the rs4149056 CT genotype may have increased concentrations of fluvastatin as compared to patients with the TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also affect fluvastatin concentrations. This annotation only covers the pharmacokinetic relationship between rs4149056 and fluvastatin and does not include evidence about clinical outcomes.
718	CC	Patients with the rs4149056 CC genotype may have increased concentrations of fluvastatin as compared to patients with the TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also affect fluvastatin concentrations. This annotation only covers the pharmacokinetic relationship between rs4149056 and fluvastatin and does not include evidence about clinical outcomes.

临床证据

id	证据的ID	总结
328	1450823509	Allele C is associated with increased concentrations of fluvastatin in healthy individuals as compared to allele T.
327	827827170	Genotype CC is not associated with increased mean peak concentration in plasma and area under the plasma concentration when exposed to fluvastatin in men as compared to genotypes CT + TT.
326	PA166262341	Annotation of CPIC Guideline for fluvastatin and CYP2C9, SLCO1B1

临床病史

id	类型	评论
1001	Update	added guideline as evidence
1000	Update	CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
999	Update	update text to include statement about DPWG
998	Create	Created

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