id	等位基因	注释文本
717	*2xN	The CYP2D62xN alleles (2x2 and 2x鈮?) are assigned as increased function alleles by CPIC. Patients carrying a 2xN allele in combination with a normal or increased function allele or a decreased function allele with an activity value of 0.5 may have a decreased response to tropisetron as compared to patients with alleles that result in a normal metabolizer phenotype. Patients carrying a 2xN allele with an activity value of 3 or greater in combination with a decreased function allele with an activity value of 0.25 or a no function allele may also have a decreased response to tropisetron as compared to patients with alleles that result in a normal metabolizer phenotype, while patients carrying a 2xN allele with an activity value of 2 in combination with a decreased function allele with an activity value of 0.25 or a no function allele may have a similar response to tropisetron as compared to patients with alleles that result in a normal metabolizer phenotype. Be aware that the CPIC guideline for tropisetron and CYP2D6 has a 'no recommendation' for CYP2D6 intermediate and poor metabolizers. Other genetic and clinical factors may also influence response to tropisetron.
716	*1xN	The CYP2D61xN alleles (1x2 and 1x鈮?) are assigned as increased function alleles by CPIC. Patients carrying a 1xN allele in combination with a normal or increased function allele or a decreased function allele with an activity value of 0.5 may have a decreased response to tropisetron as compared to patients with alleles that result in a normal metabolizer phenotype. Patients carrying a 1xN allele with an activity value of 3 or greater in combination with a decreased function allele with an activity value of 0.25 or a no function allele may also have a decreased response to tropisetron as compared to patients with alleles that result in a normal metabolizer phenotype, while patients carrying a 1xN allele with an activity value of 2 in combination with a decreased function allele with an activity value of 0.25 or a no function allele may have a similar response to tropisetron as compared to patients with alleles that result in a normal metabolizer phenotype. Be aware that the CPIC guideline for tropisetron and CYP2D6 has a 'no recommendation' for CYP2D6 intermediate and poor metabolizers. Other genetic and clinical factors may also influence response to tropisetron.
715	*1	The CYP2D61 allele is assigned as a normal function allele by CPIC. Patients carrying the 1 allele in combination with alleles that result in a normal metabolizer phenotype may have a similar response to tropisetron as compared to patients with two decreased or no function alleles or a no function allele in combination with a normal or decreased function allele, while patients carrying the *1 allele in combination with alleles that result in a normal metabolizer phenotype may have a deceased response to tropisetron as compared to patients with two increased function alleles or an increased function allele in combination with a normal function allele or a deceased function allele with an activity value of 0.5 or patients with an increased function allele with an activity value of 3 or greater in combination with a no function allele or a decreased function allele with an activity value of 0.25. Be aware that the CPIC guideline for tropisetron and CYP2D6 has a 'no recommendation' for CYP2D6 intermediate and poor metabolizers. Other genetic and clinical factors may also influence response to tropisetron.

id	证据的ID	总结
325	981954714	CYP2D6 1/1xN is associated with decreased response to ondansetron or tropisetron in people with Neoplasms.
324	PA166161955	Annotation of CPIC Guideline for tropisetron and CYP2D6

id	类型	评论
997	Update	CA score added as part of scoring system release. LOE assigned following curator review.
996	Update	Minor edits to phenotype descriptions
995	Update	Rewrote phenotype descriptions and added CPIC guideline
994	Update	Allele descriptions. This diverges from the standard sentence given that comparison is UM vs other phenotypes not necessarily only *1
993	Create	Created. LOE = 1A because of CPIC guideline for CYP2D6 and tropisetron.

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