庆大霉素,临床注释-2,变异和临床注释数据

庆大霉素

临床注释ID

1451434860

药物名称(英)

gentamicin

变异单倍型

rs267606617

基因

MT-ND1;MT-RNR1

证据级别

1A

水平覆盖

水平修饰符

Rare Variant; Tier 1 VIP

表现型类别(英)

Toxicity

表现型类别

毒性

分数

108

PMID计数

28

计数的证据

29

表现型

耳毒性

表现型(英)

Ototoxicity

最新日期

2021/6/15 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/1451434860

专业人口(英)

Pediatric

专业人口

儿科

临床等位基因

id	等位基因	注释文本
671	G	The rs267606617 G allele (also known as the 1555G allele) is assigned as a MT-RNR1 increased risk of aminoglycoside-induced hearing loss allele by CPIC. Patients with the G allele may have an increased risk of experiencing hearing loss when treated with gentamicin as compared to patients with the A allele. However, conflicting evidence has been reported. MT-RNR1 is a mitochondrial gene and is inherited as a haploid (i.e. there is only ever one allele present). Other genetic and clinical factors may also influence risk of hearing loss when treated with gentamicin.
670	A	The rs267606617 A allele (also known as the 1555A allele) is assigned as a MT-RNR1 normal risk of aminoglycoside-induced hearing loss allele by CPIC. Patients with the A allele may have a decreased, but not absent, risk of experiencing hearing loss when treated with gentamicin as compared to patients with the G allele. However, conflicting evidence has been reported. MT-RNR1 is a mitochondrial gene and is inherited as a haploid (i.e. there is only ever one allele present). Other genetic and clinical factors may also influence risk of hearing loss when treated with gentamicin.

临床证据

id	证据的ID	总结
1068	1444697639	Allele G is associated with increased risk of Ototoxicity when treated with gentamicin in infants as compared to allele A.
1067	1449732298	Allele G is associated with Ototoxicity when treated with aminoglycoside antibacterials or gentamicin as compared to allele A.
1066	1444696940	Allele G is associated with Ototoxicity when treated with gentamicin, kanamycin or streptomycin as compared to allele A.
1065	1444697282	Allele G is associated with Ototoxicity when treated with aminoglycoside antibacterials or gentamicin as compared to allele A.
1064	1184510153	Allele G is associated with Ototoxicity when treated with aminoglycoside antibacterials, gentamicin, kanamycin or streptomycin in children as compared to allele A.
1063	1444697353	Allele G is associated with Ototoxicity when treated with gentamicin or streptomycin in children with as compared to allele A.
1062	PA166229081	Annotation of CPIC Guideline for amikacin, gentamicin, kanamycin, paromomycin, plazomicin, streptomycin, tobramycin and MT-RNR1
645	1451440143	Allele G is associated with increased risk of Ototoxicity when treated with gentamicin.
644	1451440094	Allele G is associated with increased risk of Ototoxicity when treated with gentamicin.
643	1451438424	Allele G is associated with increased risk of Ototoxicity when treated with aminoglycoside antibacterials, gentamicin, kanamycin or streptomycin.
642	1451437860	Allele G is associated with increased affinity to MT-RNR1 of gentamicin, kanamycin, neomycin, paromomycin, streptomycin or tobramycin.
641	1451437800	Allele G is associated with increased risk of Ototoxicity when treated with aminoglycoside antibacterials, gentamicin or streptomycin.
640	1451437709	Allele G is associated with increased risk of Ototoxicity due to gentamicin.
639	1451437580	Allele G is associated with increased risk of Ototoxicity when treated with aminoglycoside antibacterials, gentamicin, kanamycin or streptomycin.
638	1451436400	Allele G is associated with increased affinity to MT-RNR1 of gentamicin, hygromycin b, kanamycin, neomycin, paromomycin or tobramycin.
637	1444697006	Allele G is associated with Ototoxicity when treated with amikacin, gentamicin, kanamycin, neomycin or streptomycin as compared to allele A.
636	1444697622	Allele G is associated with Ototoxicity when treated with amikacin, gentamicin or tobramycin in children with Cystic Fibrosis as compared to allele A.
635	1444697495	Allele G is associated with Ototoxicity when treated with aminoglycoside antibacterials or gentamicin as compared to allele A.
634	1444697463	Allele G is not associated with Ototoxicity when treated with gentamicin in infants as compared to allele A.
633	1444697449	Allele G is associated with Ototoxicity when treated with gentamicin in infants as compared to allele A.
632	1444697442	Allele G is associated with Ototoxicity when treated with amikacin, gentamicin or streptomycin as compared to allele A.
631	1444697293	Allele G is associated with Ototoxicity when treated with gentamicin or streptomycin as compared to allele A.
630	1444697250	Allele G is associated with Ototoxicity when treated with gentamicin or streptomycin as compared to allele A.
629	1444697241	Allele G is associated with Ototoxicity when treated with aminoglycoside antibacterials, gentamicin or streptomycin as compared to allele A.
628	1444697228	Allele G is associated with Ototoxicity when treated with aminoglycoside antibacterials, gentamicin or streptomycin as compared to allele A.
627	1444697188	Allele G is associated with Ototoxicity when treated with gentamicin, kanamycin or streptomycin as compared to allele A.
626	1444697155	Allele G is associated with Ototoxicity when treated with gentamicin, kanamycin or streptomycin as compared to allele A.
625	1444697136	Allele G is associated with Ototoxicity when treated with aminoglycoside antibacterials, gentamicin, kanamycin or streptomycin as compared to allele A.
624	1444697089	Allele G is associated with Ototoxicity when treated with aminoglycoside antibacterials or gentamicin as compared to allele A.

临床病史

id	类型	评论
918	Update	Corrected typo
917	Update	Added CPIC guideline to evidence and edited phenotype descriptions
916	Update	Added PMID 26497601 to evidence
915	Update	Added PMID 24252789 to evidence
914	Update	Added PMID 21205314 to evidence
913	Update	Added PMID 19687236 to evidence
912	Update	Added PMID 18386806 to evidence
911	Update	Added PMID 17723226 to evidence
910	Update	Added PMID 16152638 to evidence
909	Update	Added PMID 9315872 to evidence
908	Note	Checked by second curator before approval
907	Create	Created

最新招商产品更多>>