甲氨蝶呤,临床注释-2,变异和临床注释数据

甲氨蝶呤

临床注释ID

981202609

药物名称(英)

methotrexate

变异单倍型

rs4673993

基因

ATIC

证据级别

2B

水平覆盖

水平修饰符

表现型类别(英)

Efficacy

表现型类别

功效

分数

11.875

PMID计数

5

计数的证据

5

表现型

关节炎，类风湿

表现型(英)

Arthritis, Rheumatoid

最新日期

2021/3/24 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/981202609

专业人口(英)

专业人口

临床等位基因

id	等位基因	注释文本
820	TT	Patients with the rs4673993 TT genotype and Rheumatoid Arthritis may have decreased response when treated with methotrexate as compared to patients with the CC genotype. Other genetic and clinical factors may also influence methotrexate response.
819	CT	Patients with the rs4673993 CT genotype and Rheumatoid Arthritis may have decreased response when treated with methotrexate as compared to patients with the CC genotype. Other genetic and clinical factors may also influence methotrexate response.
818	CC	Patients with the rs4673993 CC genotype and Rheumatoid Arthritis may have increased response when treated with methotrexate as compared to patients with the TT genotype. Other genetic and clinical factors may also influence methotrexate response.

临床证据

id	证据的ID	总结
818	1448589833	Genotype CC is associated with increased response to methotrexate in people with Arthritis, Rheumatoid as compared to genotypes CT + TT.
817	1448266203	Genotypes CT + TT is associated with decreased response to methotrexate in people with Arthritis, Rheumatoid as compared to genotype CC.
816	769173673	Allele C is associated with increased response to methotrexate in people with Arthritis, Rheumatoid as compared to allele T.
815	769153041	Allele C is associated with decreased risk of Disease Activity when treated with methotrexate in people with Arthritis, Rheumatoid as compared to allele T.
814	1451258120	Genotype CC is associated with increased response to methotrexate in people with Arthritis, Rheumatoid as compared to genotypes CT + TT.

临床病史

id	类型	评论
1221	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1220	Update	Added rs number to text and conflicting evidence statement. Conformed to template.
1219	Update	Included 3 new studies. Updated format.

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