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华法林
临床注释ID
982030369
药物名称(英)
warfarin
变异单倍型
rs12777823
基因
证据级别
1A
水平覆盖
水平修饰符
表现型类别(英)
Dosage
表现型类别
剂量
分数
109.25
PMID计数
5
计数的证据
7
表现型
表现型(英)
最新日期
2021/4/12 0:00:00
URL
https://www.pharmgkb.org/clinicalAnnotation/982030369
专业人口(英)
专业人口
临床等位基因
id等位基因注释文本
1042 GG Patients with the rs12777823 GG genotype may require a higher dose of warfarin in African Americans as compared to patients with the AA or AG genotype. Other genetic and clinical factors may also influence warfarin dosage.
1041 AG Patients with the rs12777823 AG genotype may require a lower dose of warfarin in African Americans as compared to patients with the GG genotype. Other genetic and clinical factors may also influence warfarin dosage.
1040 AA Patients with the rs12777823 AA genotype may require a lower dose of warfarin in African Americans as compared to patients with the GG genotype. Other genetic and clinical factors may also influence warfarin dosage.
临床证据
id证据的ID总结
4853 1447952633 Genotypes AA + AG are associated with decreased dose of warfarin as compared to genotype GG.
4852 1445296716 Genotypes AA + AG are associated with decreased dose of warfarin as compared to genotype GG.
4851 1185235783 Genotypes AA + AG is associated with decreased dose of warfarin as compared to genotype GG.
4850 982030322 Allele A is associated with reduced warfarin dose in African Americans, independent of CYP2C9*2 and CYP2C9*3. when treated with warfarin as compared to allele G.
4849 982030316 Allele A is associated with reduced warfarin dose in African Americans, independent of CYP2C9*2 and CYP2C9*3. when treated with warfarin as compared to allele G.
4848 1451408520 Allele A is associated with dose of warfarin as compared to allele G.
4847 PA166104949 Annotation of CPIC Guideline for warfarin and CYP2C9, CYP4F2, VKORC1
临床病史
id类型评论
817 Update Removed VA with CYP2C18 tagged (1448636878) and replaced with equivalent annotation with no gene tag (1451408520).
816 Update CA score added as part of scoring system release. LOE assigned following curator review.
815 Update added guideline as evidence, updated text
814 Update changed level based on score
813 Update Added PMIDs 26877068 and 28686080 to evidence
812 Update Move to level 1A due to inclusion in CPIC warfarin guideline
811 Update Updated OMB race to appropriate biogeographical group

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