洛伐他汀；洛伐他汀酸,临床注释-2,变异和临床注释数据

洛伐他汀；洛伐他汀酸

临床注释ID

1451678112

药物名称(英)

lovastatin;lovastatin acid

变异单倍型

rs4149056

基因

SLCO1B1

证据级别

水平覆盖

水平修饰符

Tier 1 VIP

表现型类别(英)

Metabolism/PK

表现型类别

代谢/PK

分数

103.5

PMID计数

计数的证据

表现型

表现型(英)

最新日期

2022/2/10 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/1451678112

专业人口(英)

专业人口

临床等位基因

id	等位基因	注释文本
999	TT	Patients with the rs4149056 TT genotype may have decreased concentration of lovastatin acid as compared to patients with the CC or CT genotype. Other genetic and clinical factors may also influence the metabolism of lovastatin. This annotation only covers the pharmacokinetic relationship between rs4149056 and lovastatin acid or lovastatin and does not include evidence about clinical outcomes.
998	CT	Patients with the rs4149056 CT genotype may have increased concentration of lovastatin acid as compared to patients with the TT genotype. Other genetic and clinical factors may also influence the metabolism of lovastatin. This annotation only covers the pharmacokinetic relationship between rs4149056 and lovastatin acid or lovastatin and does not include evidence about clinical outcomes.
997	CC	Patients with the rs4149056 CC genotype may have increased concentration of lovastatin acid as compared to patients with the TT genotype. Other genetic and clinical factors may also influence the metabolism of lovastatin. This annotation only covers the pharmacokinetic relationship between rs4149056 and lovastatin acid or lovastatin and does not include evidence about clinical outcomes.

临床证据

id	证据的ID	总结
1686	1444713578	SLCO1B1 5/15 + 15/15 are associated with increased exposure to lovastatin acid in healthy individuals as compared to SLCO1B1 1/1.
1685	1448601968	Genotypes CC + CT is associated with increased concentrations of lovastatin acid in healthy individuals as compared to genotype TT.
1684	PA166262241	Annotation of CPIC Guideline for lovastatin and SLCO1B1

临床病史

id	类型	评论
753	Create	Created

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