卡那霉素,临床注释-2,变异和临床注释数据

id	等位基因	注释文本
964	G	The rs267606617 G allele (also known as the 1555G allele) is assigned as a MT-RNR1 increased risk of aminoglycoside-induced hearing loss allele by CPIC. Patients with the G allele may have an increased risk of experiencing hearing loss when treated with kanamycin as compared to patients with the A allele. MT-RNR1 is a mitochondrial gene and is inherited as a haploid (i.e. there is only ever one allele present). Other genetic and clinical factors may also influence risk of hearing loss when treated with kanamycin.
963	A	The rs267606617 A allele (also known as the 1555A allele) is assigned as a MT-RNR1 normal risk of aminoglycoside-induced hearing loss allele by CPIC. Patients with the A allele may have a decreased, but not absent, risk of experiencing hearing loss when treated with kanamycin as compared to patients with the G allele. MT-RNR1 is a mitochondrial gene and is inherited as a haploid (i.e. there is only ever one allele present). Other genetic and clinical factors may also influence risk of hearing loss when treated with kanamycin.

等位基因

注释文本

The rs267606617 G allele (also known as the 1555G allele) is assigned as a MT-RNR1 increased risk of aminoglycoside-induced hearing loss allele by CPIC. Patients with the G allele may have an increased risk of experiencing hearing loss when treated with kanamycin as compared to patients with the A allele. MT-RNR1 is a mitochondrial gene and is inherited as a haploid (i.e. there is only ever one allele present). Other genetic and clinical factors may also influence risk of hearing loss when treated with kanamycin.

963

The rs267606617 A allele (also known as the 1555A allele) is assigned as a MT-RNR1 normal risk of aminoglycoside-induced hearing loss allele by CPIC. Patients with the A allele may have a decreased, but not absent, risk of experiencing hearing loss when treated with kanamycin as compared to patients with the G allele. MT-RNR1 is a mitochondrial gene and is inherited as a haploid (i.e. there is only ever one allele present). Other genetic and clinical factors may also influence risk of hearing loss when treated with kanamycin.

id	证据的ID	总结
1632	1451438424	Allele G is associated with increased risk of Ototoxicity when treated with aminoglycoside antibacterials, gentamicin, kanamycin or streptomycin.
1631	1451437860	Allele G is associated with increased affinity to MT-RNR1 of gentamicin, kanamycin, neomycin, paromomycin, streptomycin or tobramycin.
1630	1451437580	Allele G is associated with increased risk of Ototoxicity when treated with aminoglycoside antibacterials, gentamicin, kanamycin or streptomycin.
1629	1451437476	Allele G is associated with increased affinity to MT-RNR1 of kanamycin, neomycin, paromomycin or tobramycin.
1628	1451436400	Allele G is associated with increased affinity to MT-RNR1 of gentamicin, hygromycin b, kanamycin, neomycin, paromomycin or tobramycin.
1627	1444697006	Allele G is associated with Ototoxicity when treated with amikacin, gentamicin, kanamycin, neomycin or streptomycin as compared to allele A.
1626	1444697188	Allele G is associated with Ototoxicity when treated with gentamicin, kanamycin or streptomycin as compared to allele A.
1625	1444697155	Allele G is associated with Ototoxicity when treated with gentamicin, kanamycin or streptomycin as compared to allele A.
1624	1444697136	Allele G is associated with Ototoxicity when treated with aminoglycoside antibacterials, gentamicin, kanamycin or streptomycin as compared to allele A.
1623	1444696940	Allele G is associated with Ototoxicity when treated with gentamicin, kanamycin or streptomycin as compared to allele A.
1622	1184510153	Allele G is associated with Ototoxicity when treated with aminoglycoside antibacterials, gentamicin, kanamycin or streptomycin in children as compared to allele A.
1621	PA166229081	Annotation of CPIC Guideline for amikacin, gentamicin, kanamycin, paromomycin, plazomicin, streptomycin, tobramycin and MT-RNR1

证据的ID

总结

1632

1451438424

Allele G is associated with increased risk of Ototoxicity when treated with aminoglycoside antibacterials, gentamicin, kanamycin or streptomycin.

1631

1451437860

Allele G is associated with increased affinity to MT-RNR1 of gentamicin, kanamycin, neomycin, paromomycin, streptomycin or tobramycin.

1630

1451437580

Allele G is associated with increased risk of Ototoxicity when treated with aminoglycoside antibacterials, gentamicin, kanamycin or streptomycin.

1629

1451437476

Allele G is associated with increased affinity to MT-RNR1 of kanamycin, neomycin, paromomycin or tobramycin.

1628

1451436400

Allele G is associated with increased affinity to MT-RNR1 of gentamicin, hygromycin b, kanamycin, neomycin, paromomycin or tobramycin.

1627

1444697006

Allele G is associated with Ototoxicity when treated with amikacin, gentamicin, kanamycin, neomycin or streptomycin as compared to allele A.

1626

1444697188

Allele G is associated with Ototoxicity when treated with gentamicin, kanamycin or streptomycin as compared to allele A.

1625

1444697155

Allele G is associated with Ototoxicity when treated with gentamicin, kanamycin or streptomycin as compared to allele A.

1624

1444697136

Allele G is associated with Ototoxicity when treated with aminoglycoside antibacterials, gentamicin, kanamycin or streptomycin as compared to allele A.

1623

1444696940

Allele G is associated with Ototoxicity when treated with gentamicin, kanamycin or streptomycin as compared to allele A.

1622

1184510153

Allele G is associated with Ototoxicity when treated with aminoglycoside antibacterials, gentamicin, kanamycin or streptomycin in children as compared to allele A.

1621

PA166229081

Annotation of CPIC Guideline for amikacin, gentamicin, kanamycin, paromomycin, plazomicin, streptomycin, tobramycin and MT-RNR1

id	类型	评论
709	Update	Added CPIC guideline to evidence and edited phenotype descriptions. Awaiting curator check before approval.
708	Update	Added PMID 21205314 to evidence
707	Update	Added PMID 19687236 to evidence
706	Update	Added PMID 16152638 to evidence
705	Update	Added PMID 12127547 to evidence
704	Update	Added PMID 9315872 to evidence
703	Create	Created