华法林,临床注释-2,变异和临床注释数据

华法林

临床注释ID

655385400

药物名称(英)

warfarin

变异单倍型

rs2108622

基因

CYP4F2

证据级别

1A

水平覆盖

水平修饰符

Tier 1 VIP

表现型类别(英)

Dosage

表现型类别

剂量

分数

170

PMID计数

69

计数的证据

72

表现型

表现型(英)

最新日期

2021/3/24 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/655385400

专业人口(英)

Pediatric

专业人口

儿科

临床等位基因

id	等位基因	注释文本
811	TT	Patients with the rs2108622 TT genotype may have increased warfarin dosage requirements as compared to patients with the CC or CT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also affect warfarin dosage requirements.
810	CT	Patients with the rs2108622 CT genotype may have increased warfarin dosage requirements as compared to patients with the CC genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also affect warfarin dosage requirements.
809	CC	Patients with the rs2108622 CC genotype may have decreased warfarin dosage requirements as compared to patients with the CT or TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also affect warfarin dosage requirements.

临床证据

id	证据的ID	总结
1424	1447682700	CYP4F2 3 is associated with increased dose of warfarin as compared to CYP4F2 1.
1423	827783872	CYP4F2 3/3 is associated with increased dose of warfarin in people with a stable international normalized ratio of between two and three as compared to CYP4F2 1/1.
1422	1450370810	Allele T is not associated with dose of warfarin as compared to allele C.
1421	1450186421	Genotypes CT + TT are associated with increased dose of acenocoumarol or warfarin as compared to genotype CC.
1420	1449575733	Allele T is not associated with dose of warfarin as compared to allele C.
1419	1449269209	Allele T is associated with dose of warfarin as compared to allele C.
1418	1449259246	Allele T is associated with increased dose of warfarin as compared to allele C.
1417	1449251596	Allele T is not associated with dose of warfarin as compared to allele C.
1416	1449192000	Allele T is associated with increased dose of warfarin in people with Cardiovascular Diseases as compared to allele C.
1415	1449191473	Allele T is associated with increased dose of warfarin in people with Cardiovascular Diseases as compared to allele C.
1414	1449190771	Allele T is not associated with dose of acenocoumarol or warfarin in people with venous thromboembolism as compared to allele C.
1413	1449005218	Genotypes CC + CT are associated with decreased dose of warfarin as compared to genotype TT.
1412	1449005167	Genotype TT is associated with increased dose of warfarin as compared to genotypes CC + CT.
1411	1448633907	Allele T is associated with increased dose of warfarin as compared to allele C.
1410	1448624178	Genotype TT is associated with increased dose of warfarin in people with Atrial Fibrillation, heart valve replacement, Hypertension, Pulmonary, Pulmonary Embolism and Venous Thrombosis as compared to genotype CC.
1409	1448615563	Genotype CC is associated with decreased dose of warfarin in people with heart valve replacement as compared to genotypes CT + TT.
1408	1448602262	Genotypes CT + TT is not associated with increased dose of warfarin in people with Atrial Fibrillation, Cardiomyopathies, heart valve replacement, Peripheral Vascular Diseases, Pulmonary Embolism and Venous Thrombosis as compared to genotype CC.
1407	1448431513	Genotypes CC + CT are associated with decreased dose of warfarin in people with heart valve replacement as compared to genotype TT.
1406	1448276458	Allele T is associated with dose of warfarin.
1405	1448275984	Genotype CC is associated with decreased dose of warfarin as compared to genotype TT.
1404	1448268037	Genotype TT is associated with increased dose of warfarin in people with Atrial Fibrillation as compared to genotypes CC + CT.
1403	1448257102	Genotypes CT + TT are associated with increased dose of warfarin as compared to genotype CC.
1402	1448109663	Allele C is associated with dose of warfarin as compared to allele T.
1401	1448108296	Genotypes CT + TT is not associated with dose of warfarin in children as compared to genotype CC.
1400	1447983837	Allele T is associated with increased dose of warfarin as compared to allele C.
1399	1447952609	Genotypes CT + TT are associated with increased dose of warfarin as compared to genotype CC.
1398	1447680563	Allele T is associated with dose of warfarin as compared to allele C.
1397	1446765933	Genotype TT is associated with increased dose of warfarin as compared to genotypes CC + CT.
1396	1445296694	Genotypes CT + TT are associated with increased dose of warfarin as compared to genotype CC.
1395	1444694633	Genotypes CT + TT are not associated with dose of warfarin in people with heart valve replacement as compared to genotype CC.
1394	1185235744	Allele C is not associated with dose of warfarin in children as compared to allele T.
1393	1184756280	Allele C is associated with decreased dose of warfarin in people with heart valve replacement as compared to allele T.
1392	1184748929	Allele T is associated with increased dose of warfarin.
1391	1184654456	Allele T is not associated with increased dose of warfarin in children with Heart Diseases as compared to allele C.
1390	1184511955	Genotypes CT + TT is associated with increased dose of warfarin in healthy individuals as compared to genotype CC.
1389	1184511577	Genotypes CT + TT is associated with increased dose of warfarin as compared to genotype CC.
1388	1184510155	Genotype CT is associated with increased dose of warfarin as compared to genotype CC.
1387	1184510136	Genotypes CT + TT is associated with increased dose of warfarin as compared to genotype CC.
1386	1184510039	Genotype TT is associated with increased dose of warfarin as compared to genotypes CC + CT.
1385	1184483813	Genotype TT is associated with increased dose of warfarin as compared to genotype CC.
1384	1184482772	Genotypes CT + TT is associated with increased dose of warfarin as compared to genotype CC.
1383	1184472389	Allele T is not associated with dose of warfarin as compared to allele C.
1382	1183934923	Genotype TT is associated with higher mean warfarin daily dose requirement when treated with warfarin in children as compared to genotypes CC + CT.
1381	1183704839	Genotype TT is associated with increased dose of warfarin as compared to genotypes CC + CT.
1380	1183701528	Allele C is associated with decreased dose of warfarin in people with venous thromboembolism as compared to allele T.
1379	1183700228	Allele T is associated with increased dose of warfarin as compared to allele C.
1378	1183700033	Allele T is associated with increased dose of warfarin as compared to allele C.
1377	1183697697	Genotypes CC + CT is associated with decreased dose of warfarin in people with Cardiovascular Diseases as compared to genotype TT.
1376	827864558	Allele C is not associated with decreased dose of warfarin as compared to allele T.
1375	769182565	Genotypes CT + TT are associated with increased dose of warfarin as compared to genotype CC.
1374	608431751	Allele C is associated with dose of warfarin.
1373	699638607	Genotype CC is associated with decreased dose of warfarin as compared to genotypes CT + TT.
1372	655388324	Genotype CC is not associated with decreased required dose of warfarin as compared to genotypes CT + TT.
1371	978614465	Allele T is associated with dose of warfarin.
1370	827925134	Genotypes CT + TT are associated with increased dose of warfarin in people with Thromboembolism as compared to genotype CC.
1369	827813045	Allele C is not associated with stable warfarin dose univariately when treated with warfarin as compared to allele T.
1368	827641885	Allele T is associated with increased dose of warfarin as compared to allele C.
1367	769246303	Genotype CC is associated with decreased dose of warfarin as compared to genotype CT.
1366	982047993	Genotype CC is not associated with dose of warfarin in children as compared to genotype TT.
1365	982037942	Allele T is not associated with decreased dose of warfarin as compared to allele C.
1364	981754851	Genotype CC is associated with decreased dose of warfarin as compared to genotypes CT + TT.
1363	981502959	Allele T is not associated with therapeutic warfarin dose requirement in African-Americans when treated with warfarin as compared to allele C.
1362	981502925	Allele T is associated with a 22% increase in therapeutic warfarin dose requirement after adjustment for clinical and genetic covariates in Hispanic-Americans when treated with warfarin as compared to allele C.
1361	981500599	Allele C is not associated with dose of warfarin in people with Myocardial Infarction as compared to allele T.
1360	981489956	Genotype CC is associated with decreased dose of warfarin as compared to genotypes CT + TT.
1359	981483967	Genotypes CT + TT are associated with increased dose of warfarin in people with mechanical heart valve replacement as compared to genotype CC.
1358	981481830	Allele T is associated with increased dose of warfarin as compared to allele C.
1357	981481812	Allele T is associated with increased dose of warfarin as compared to allele C.
1356	981477999	Genotypes CT + TT are associated with 8.3% higher mean daily coumarin dose to reach a stable international normalized ratio (INR) when treated with acenocoumarol, phenprocoumon or warfarin as compared to genotype CC.
1355	981239905	Allele C is not associated with increased dose of warfarin in people with warfarin maintenance treatment as compared to allele T.
1354	PA166104949	Annotation of CPIC Guideline for warfarin and CYP2C9, CYP4F2, VKORC1
802	1448276515	CYP4F2 *3 is associated with dose of warfarin.

临床病史

id	类型	评论
1208	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1207	Update	update CA from *allele to rsID
1206	Update	added guideline as evidence, updated text
1205	Update	Added PMIDs 30506680 and 30821933 to evidence. Rewrote CA to be on star alleles rather than the rsID.
1204	Update	Added PMID 29875668
1203	Update	Reviewed. Changed to Level 1A (part of CPIC guideline).
1202	Update	Added PMID 29252193, 28973620, 23132553
1201	Update	Added PMID 27617219

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