id	等位基因	注释文本
942	TT	The A allele of this variant, when measured on plus chromosomal strand, is assigned decreased function by CPIC. Patients with the TT genotype and cancer who are treated with fluorouracil, a fluoropyrimidine-based chemotherapy, may have decreased, but not absent, risk and reduced severity of drug toxicity as compared to patients with the AA or AT genotypes. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.
941	AT	The A allele of this variant, when measured on plus chromosomal strand, is assigned decreased function by CPIC. Patients with the AT genotype and cancer who are treated with fluorouracil, a fluoropyrimidine-based chemotherapy, may have increased risk and increased severity of drug toxicity as compared to patients with the TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.
940	AA	The A allele of this variant, when measured on plus chromosomal strand, is assigned decreased function by CPIC. Patients with the AA genotype and cancer who are treated with fluorouracil, a fluoropyrimidine-based chemotherapy, may have increased risk and increased severity of drug toxicity as compared to patients with the TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.

id	证据的ID	总结
2845	1450373060	Genotype AT is associated with risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to genotype TT.
2844	1450372255	Genotypes AA + AT is associated with increased risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to genotype TT.
2843	1449716974	Genotype AT is associated with risk of Drug Toxicity when treated with fluorouracil in women with Colonic Neoplasms.
2842	1449162090	Genotype AT is not associated with risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colonic Neoplasms as compared to genotype TT.
2841	1449161738	Genotype TT is not associated with risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to genotypes AA + AT.
2840	1448255407	Allele A is associated with increased risk of Drug Toxicity when treated with capecitabine, fluorouracil or tegafur in people with Neoplasms.
2839	1448124229	Genotype AT is associated with risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
2838	1448123303	Genotype AT is associated with increased likelihood of Drug Toxicity when treated with capecitabine in people with Colorectal Neoplasms as compared to genotype TT.
2837	1448123106	Allele A is not associated with Drug Toxicity when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms.
2836	1448118919	Allele A is associated with increased severity of Drug Toxicity when treated with fluorouracil.
2835	1447991648	Allele A is associated with Drug Toxicity when treated with capecitabine or fluorouracil in people with gastroesophageal cancer.
2834	1447991448	Allele A is associated with Drug Toxicity when treated with fluorouracil in people with Neoplasms.
2833	1447988411	Allele A is associated with risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
2832	1447959064	Allele A is not associated with Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
2831	1447950006	Allele A is associated with increased severity of Drug Toxicity when treated with fluorouracil in people with Colonic Neoplasms as compared to allele T.
2830	1447945538	Genotype AT is associated with increased severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to genotype TT.
2829	1449731731	Genotype AT is associated with increased Drug Toxicity when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms as compared to genotype TT.
2828	1444607104	Genotype AT is associated with increased risk of Drug Toxicity when treated with fluorouracil in people with Colonic Neoplasms as compared to genotype TT.
2827	1184471966	Genotype AT is associated with increased risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms as compared to genotype TT.
2826	1183630516	Allele A is associated with increased risk of Drug Toxicity when treated with capecitabine, fluorouracil or tegafur in people with Neoplasms.
2825	827892780	Genotype AT is associated with increased risk of Drug Toxicity when treated with fluorouracil in people with Neoplasms as compared to genotype TT.
2824	827824687	Genotype AT is associated with increased likelihood of Drug Toxicity when treated with fluorouracil in people with Colorectal Neoplasms.
2823	982006241	Allele A is associated with increased likelihood of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to genotype TT.
2822	PA166104939	Annotation of DPWG Guideline for fluorouracil and DPYD
2821	PA166122686	Annotation of CPIC Guideline for fluorouracil and DPYD

id	类型	评论
662	Update	Added DPWG guideline as evidence
661	Update	CA score added as part of scoring system release. LOE assigned following curator review.
660	Update	Attached CPIC guideline and removed override. Added CPIC function and modified text.
659	Update	CA separated to be for fluorouracil and ADR evidence only
658	Update	Corrected typo in gene name
657	Update	updating ClinVar submission data

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