id	等位基因	注释文本
808	GG	Patients with the rs28933396 GG genotype may have a decreased, but not absent, risk for malignant hyperthermia based on this variant when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with the AG and AA genotype. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.
807	AG	Patients with the rs28933396 AG genotype may develop malignant hyperthermia when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with the GG genotype. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.
806	AA	Patients with the rs28933396 AA genotype may develop malignant hyperthermia when treated with volatile anesthetics (desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane) and/or succinylcholine as compared to patients with the GG genotype. Other genetic or clinical factors may also influence the risk for malignant hyperthermia.

id	证据的ID	总结
1353	1447987537	Allele A is associated with increased risk of Malignant Hyperthermia as compared to allele G.
1352	1447960991	Allele A is associated with increased risk of Malignant Hyperthermia as compared to allele G.
1351	1447960614	Allele A is associated with increased risk of Malignant Hyperthermia as compared to allele G.
1350	1447952537	Genotype AG is associated with increased risk of Malignant Hyperthermia as compared to genotype GG.
1349	1447947742	Genotype AG is associated with increased risk of Malignant Hyperthermia as compared to genotype GG.
1348	1447675740	Genotype AG is associated with increased risk of Malignant Hyperthermia and Myopathy, Central Core as compared to genotype GG.
1347	1447675323	Genotype AG is associated with increased risk of Malignant Hyperthermia as compared to genotype GG.
1346	1447673900	Allele A is associated with increased risk of Malignant Hyperthermia as compared to allele G.
1345	1447673865	Genotype AG is associated with increased risk of Malignant Hyperthermia as compared to genotype GG.
1344	1447672539	Allele A is associated with increased risk of Malignant Hyperthermia when exposed to enflurane and succinylcholine as compared to allele G.
1343	1447672461	Genotype AG is associated with Malignant Hyperthermia as compared to genotype GG.
1342	1447672297	Genotype AG is associated with increased risk of Malignant Hyperthermia as compared to genotype GG.
1341	1447634953	Allele A is associated with Malignant Hyperthermia as compared to allele G.
1340	1445400849	Allele A is associated with increased risk of Malignant Hyperthermia as compared to allele G.
1339	1445296975	Allele A is associated with increased risk of Malignant Hyperthermia as compared to allele G.
1338	1445124420	Allele A is associated with increased risk of Malignant Hyperthermia as compared to allele G.
1337	PA166180457	Annotation of CPIC Guideline for desflurane, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane, succinylcholine and CACNA1S, RYR1

id	类型	评论
1200	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1199	Update	Drugs kept combined based on specifics of Malignant Hyperthermia diagnostics and CPIC guideline/EMHG inclusion.
1198	Update	Assigned LOE 1A since variant listed in recommendation of CPIC guideline
1197	Update	changed wording from "may be associated with increased/decreased risk of MH" to "may/may not develop MH" and updated publications
1196	Create

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