氟尿嘧啶,临床注释-2,变异和临床注释数据

氟尿嘧啶

临床注释ID

981201946

药物名称(英)

fluorouracil

变异单倍型

rs1801158

基因

DPYD

证据级别

1A

水平覆盖

水平修饰符

Tier 1 VIP

表现型类别(英)

Toxicity

表现型类别

毒性

分数

87.75

PMID计数

13

计数的证据

14

表现型

肿瘤

表现型(英)

Neoplasms

最新日期

2021/3/24 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/981201946

专业人口(英)

专业人口

临床等位基因

id	等位基因	注释文本
912	TT	Both variants of rs1801158 are assigned normal function by CPIC. Patients with the TT genotype and cancer who are treated with fluorouracil, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the CT or CC genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.
911	CT	Both variants of rs1801158 are assigned normal function by CPIC. Patients with the CT genotype and cancer who are treated with fluorouracil, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the CC or TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.
910	CC	Both variants of rs1801158 are assigned normal function by CPIC. Patients with the CC genotype and cancer who are treated with fluorouracil, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the CT or TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.

临床证据

id	证据的ID	总结
3453	1449732020	Genotype CT is associated with increased risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms as compared to genotype CC.
3452	1449162040	Genotypes CT + TT is not associated with risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colonic Neoplasms as compared to genotype CC.
3451	1449161763	Genotype CC is not associated with risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to genotypes CT + TT.
3450	1448262697	Allele T is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
3449	1448126269	Allele T is not associated with severity of Drug Toxicity when treated with fluorouracil in people with Colonic Neoplasms and Colorectal Neoplasms as compared to allele C.
3448	1448124239	Genotype CT is associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
3447	1450959905	Genotype CT is associated with increased risk of Drug Toxicity when treated with fluorouracil in people with Neoplasms as compared to genotype CC.
3446	1450954660	Allele T is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
3445	1450954540	Genotype CT is not associated with severity of Drug Toxicity when treated with fluorouracil in people with Neoplasms as compared to genotype CC.
3444	1450954000	Allele T is not associated with severity of Drug Toxicity when treated with fluorouracil.
3443	1450953025	Allele T is not associated with risk of Drug Toxicity when treated with capecitabine, fluorouracil or tegafur in people with Neoplasms as compared to allele C.
3442	827892923	Genotype CT is associated with Drug Toxicity when treated with fluorouracil in people with Neoplasms as compared to genotype CC.
3441	1447945626	Allele T is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to allele C.
3440	PA166122686	Annotation of CPIC Guideline for fluorouracil and DPYD

临床病史

id	类型	评论
622	Update	CA score added as part of scoring system release. LOE assigned following curator review.
621	Update	Attached CPIC guideline and removed override. Added CPIC function and modified text.
620	Update	CA for fluorouracil and ADR evidence (score -10.25); changed to level 1A since included in CPIC guideline as normal function variant
619	Update	update PMID16115930 VA to use rsID for *4
618	Update	removed 2A/4 VA 1448124213
617	Update	updated evidence to move *4 annotations to rs1801158
616	Update	Updated OMB race to appropriate biogeographical group
615	Update

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