id	等位基因	注释文本
1219	TT	Both variants of rs2297595 are assigned normal function by CPIC. Patients with the TT genotype and cancer who are treated with fluorouracil, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the CT or CC genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.
1218	CT	Both variants of rs2297595 are assigned normal function by CPIC. Patients with the CT genotype and cancer who are treated with fluorouracil, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the CC or TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.
1217	CC	Both variants of rs2297595 are assigned normal function by CPIC. Patients with the CC genotype and cancer who are treated with fluorouracil, a fluoropyrimidine-based chemotherapy, may not have altered risk of drug toxicity as compared to patients with the CT or TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of drug toxicity.

id	证据的ID	总结
3427	1450371940	Genotypes CC + CT is not associated with risk of Neutropenia when treated with capecitabine or fluorouracil in people with Neoplasms as compared to genotype TT.
3426	1449732006	Genotypes CC + CT is not associated with Drug Toxicity when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms as compared to genotype TT.
3425	1449162069	Genotypes CC + CT is not associated with risk of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colonic Neoplasms as compared to genotype TT.
3424	1449161605	Genotype TT is associated with increased severity of Diarrhea when treated with capecitabine or fluorouracil in people with Neoplasms as compared to genotypes CC + CT.
3423	1448262663	Allele C is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
3422	1448126260	Allele C is not associated with severity of Drug Toxicity when treated with fluorouracil in people with Colonic Neoplasms and Colorectal Neoplasms as compared to allele T.
3421	1448124647	Allele C is not associated with increased severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms as compared to allele T.
3420	1448124184	Allele C is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to allele T.
3419	1448123099	Allele T is associated with Drug Toxicity when treated with capecitabine or fluorouracil in people with Colorectal Neoplasms.
3418	1448122697	Allele C is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
3417	1448119062	Allele C is not associated with severity of Drug Toxicity when treated with fluorouracil.
3416	1447991474	Allele C is associated with Drug Toxicity when treated with fluorouracil in people with Neoplasms.
3415	1447945605	Allele C is not associated with severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms as compared to allele T.
3414	827892931	Genotype CT is associated with Drug Toxicity when treated with fluorouracil in people with Neoplasms as compared to genotype TT.
3413	769169640	Genotypes CC + CT are associated with increased severity of Drug Toxicity when treated with capecitabine or fluorouracil in people with Breast Neoplasms and gastroesophageal cancer as compared to genotype TT.
3412	981398678	Genotypes CC + CT are associated with decreased likelihood of Neutropenia when treated with fluorouracil in women with Neoplasms as compared to genotype TT.
3411	1447987449	Genotype CT is not associated with Drug Toxicity when treated with capecitabine, fluorouracil or s 1 (combination) in people with Stomach Neoplasms as compared to genotype TT.
3410	1449161585	Genotypes CT + TT is associated with increased likelihood of hand-foot syndrome, mucositis or Peripheral Nervous System Diseases when treated with capecitabine or fluorouracil in people with Neoplasms as compared to genotype CC.
3409	PA166122686	Annotation of CPIC Guideline for fluorouracil and DPYD

id	类型	评论
610	Update	Corrected LOE
609	Update	CA score added as part of scoring system release. LOE assigned following curator review.
608	Update	Overrode level to 1A
607	Update	Attached CPIC. Added conflicting evidence and text midifcations. Left override.
606	Update	CA for ADR and fluorouracil evidence; changed to level 1A since variant is included in the CPIC guideline (normal function)
605	Update

最新招商产品更多>>