id	等位基因	注释文本
1213	TT	Patients with the rs3745274 TT genotype may have an increased risk for efavirenz-induced side effects, including sleep- and central nervous system-related side effects, as compared to patients with the GG genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence the risk of efavirenz toxicity.
1212	GT	Patients with the rs3745274 GT genotype may have an increased risk of efavirenz-induced side effects, including sleep- and central nervous system-related side effects, as compared to patients with the GG genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of efavirenz toxicity.
1211	GG	Patients with the rs3745274 GG genotype may have a decreased, but not absent risk of efavirenz-induced side effects, including sleep- and central nervous system-related side effects, as compared to patients with the GT or TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of efavirenz toxicity.

id	证据的ID	总结
3649	1183634134	Genotype GT is associated with increased likelihood of Sleep Disorders when treated with efavirenz in people with HIV Infections as compared to genotype GG.
3648	1183614660	Allele T is associated with risk of central nervous system adverse side effects when treated with efavirenz in people with HIV Infections as compared to allele G.
3647	827922962	Allele T is associated with increased risk of Central Nervous System Diseases when treated with efavirenz in people with HIV Infections as compared to allele G.
3646	827922504	Genotype TT is associated with early (< 3 months) termination of efavirenz therapy when treated with efavirenz as compared to genotypes GG + GT.
3645	827811208	Genotype TT is not associated with increased likelihood of Drug Toxicity when treated with efavirenz, lamivudine and stavudine in people with HIV Infections as compared to genotypes GG + GT.
3644	827695768	Genotype TT is associated with increased likelihood of Fatigue when treated with efavirenz in people with HIV Infections as compared to genotypes GG + GT.
3643	827695756	Genotype TT is associated with increased likelihood of Sleep Disorders when treated with efavirenz in people with HIV Infections as compared to genotypes GG + GT.
3642	PA166182603	Annotation of CPIC Guideline for efavirenz and CYP2B6
3405	1184168515	CYP2B6 1 is not associated with Neurotoxicity Syndromes when treated with efavirenz in people with HIV as compared to CYP2B6 6.
3404	1449156757	Genotype GT is associated with increased risk of Toxic liver disease when treated with efavirenz as compared to genotype GG.
3403	1449156714	Allele T is associated with Status Epilepticus when treated with efavirenz as compared to allele G.
3402	1449156706	Genotype GT is associated with Sleep Disorders when treated with efavirenz as compared to genotype GG.
3401	1449156692	Genotypes GT + TT are not associated with Drug Toxicity when treated with efavirenz in children with HIV Infections as compared to genotype GG.
3400	1449156651	Genotypes GT + TT are associated with increased likelihood of Central Nervous System Diseases when treated with efavirenz in people with HIV Infections as compared to genotype GG.
3399	1449156613	Allele T is not associated with increased likelihood of Central Nervous System Diseases when treated with efavirenz in people with HIV Infections as compared to allele G.
3398	1449156598	Genotypes GT + TT are not associated with increased likelihood of Central Nervous System Diseases when treated with efavirenz in people with HIV Infections as compared to genotype GG.
3397	1448998455	Genotype GT is associated with Central Nervous System Diseases when treated with efavirenz in men with HIV Infections as compared to genotype GG.
3396	1448998433	Genotype TT is associated with increased likelihood of Psychotic Disorders when treated with efavirenz in women with HIV Infections as compared to genotype GG.
3395	1448997704	Genotype GT is associated with increased likelihood of Psychotic Disorders when treated with efavirenz in women HIV Infections as compared to genotype GG.
3394	1448997475	Genotype TT is associated with increased likelihood of Central Nervous System Diseases when treated with efavirenz in people with HIV Infections as compared to genotype GG.
3393	1448997441	Genotype TT is associated with increased likelihood of Epilepsy, Absence when treated with efavirenz in children with HIV Infections as compared to genotype GG.
3392	1448997115	Genotypes GT + TT are associated with increased likelihood of Central Nervous System Diseases when treated with efavirenz in children with HIV Infections as compared to genotype GG.
3391	1448994229	Genotypes GT + TT are not associated with increased risk of Depression when treated with efavirenz in people with HIV Infections as compared to genotype GG.
3390	1448993713	Genotype TT is not associated with increased risk of Central Nervous System Diseases when treated with efavirenz or nevirapine in people with HIV Infections.
3389	1448993680	Genotype TT is not associated with increased risk of Central Nervous System Diseases when treated with efavirenz in people with HIV Infections as compared to genotype GG.
3388	1448636188	Genotype TT is associated with decreased likelihood of Drug Toxicity when treated with efavirenz in people with HIV Infections as compared to genotype GG.
3387	1448633500	Genotypes GT + TT are associated with increased risk of Central Nervous System Diseases when treated with efavirenz in people with HIV Infections as compared to genotype GG.
3386	1448265875	Allele T is not associated with risk of Neurotoxicity Syndromes when treated with efavirenz in people with HIV Infections as compared to allele G.
3385	1184987941	Allele T is associated with increased likelihood of Disorders of Excessive Somnolence when treated with efavirenz in people with HIV Infections.
3384	1184473278	Genotype TT is associated with increased risk of Central Nervous System Diseases when treated with efavirenz in men with HIV Infections.
3383	1183634227	Genotypes GT + TT are not associated with risk of Neurotoxicity Syndromes when treated with efavirenz in people with HIV Infections as compared to genotype GG.

id	类型	评论
602	Update	CA score added as part of scoring system release. LOE assigned following curator review.
601	Update	added guideline as evidence, updated text
600	Update	changed level based on CPIC
599	Update	updating ClinVar submission data

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