依法韦仑,临床注释-2,变异和临床注释数据

依法韦仑

临床注释ID

827923032

药物名称(英)

efavirenz

变异单倍型

rs3745274

基因

CYP2B6

证据级别

1A

水平覆盖

水平修饰符

Tier 1 VIP

表现型类别(英)

Metabolism/PK

表现型类别

代谢/PK

分数

229.0625

PMID计数

77

计数的证据

89

表现型

艾滋病毒感染

表现型(英)

HIV Infections

最新日期

2021/3/24 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/827923032

专业人口(英)

Pediatric

专业人口

儿科

临床等位基因

id	等位基因	注释文本
1210	TT	Patients with the rs3745274 TT genotype and HIV infection may have increased plasma concentrations and decreased clearance of efavirenz as compared to patients with the GT or GG genotype. Other genetic and clinical factors may also influence the metabolism of efavirenz. This annotation only covers the pharmacokinetic relationship between rs3745274 and efavirenz and does not include evidence about clinical outcomes.
1209	GT	Patients with the rs3745274 GT genotype and HIV infection may have increased plasma concentrations and decreased clearance of efavirenz as compared to patients with the GG genotype. Other genetic and clinical factors may also influence the metabolism of efavirenz. This annotation only covers the pharmacokinetic relationship between rs3745274 and efavirenz and does not include evidence about clinical outcomes.
1208	GG	Patients with the rs3745274 GG genotype and HIV infection may have decreased plasma concentrations and increased clearance of efavirenz as compared to patients with the GT or TT genotype. Other genetic and clinical factors may also influence the metabolism of efavirenz. This annotation only covers the pharmacokinetic relationship between rs3745274 and efavirenz and does not include evidence about clinical outcomes.

临床证据

id	证据的ID	总结
4183	981480729	Genotype TT is associated with increased exposure of efavirenz in women with HIV Infections as compared to genotypes GG + GT.
4182	981478640	Genotype TT is associated with increased plasma concentration of efavirenz in people with HIV Infections as compared to genotype GG.
4181	1448107499	Genotype GG is associated with increased dose of efavirenz in people with HIV Infections as compared to genotypes GT + TT.
4180	1448104256	Genotype GG is associated with increased clearance of efavirenz in people with HIV Infections as compared to genotypes GT + TT.
4179	1447680746	Allele T is associated with increased concentrations of efavirenz in people with HIV Infections as compared to allele G.
4178	1447680376	Genotype TT is associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotypes GG + GT.
4177	1446905193	Allele T is associated with increased concentrations of efavirenz in people with HIV Infections as compared to allele G.
4176	PA166182603	Annotation of CPIC Guideline for efavirenz and CYP2B6
3641	1449275102	Genotype TT is associated with increased concentrations of efavirenz in people with Hepatitis B and HIV Infections as compared to genotypes GG + GT.
3640	1449156764	Genotype GT is associated with increased concentrations of efavirenz as compared to genotype GG.
3639	1448998489	Genotypes GT + TT are associated with increased concentrations of efavirenz in children with HIV Infections as compared to genotype GG.
3638	1448998482	Genotypes GT + TT are associated with decreased clearance of efavirenz in children with HIV Infections as compared to genotype GG.
3637	1448998466	Genotype GT is associated with increased concentrations of efavirenz in men with HIV Infections as compared to genotype GG.
3636	1448998441	Genotype TT is associated with increased concentrations of efavirenz in women with HIV Infections as compared to genotype GG.
3635	1448998426	Genotypes GT + TT are associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotype GG.
3634	1448997797	Genotype TT is associated with increased exposure to efavirenz in people with HIV Infections as compared to genotypes GG + GT.
3633	1448997777	Genotypes GT + TT are associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotype GG.
3632	1448997743	Genotypes GT + TT are associated with increased exposure to efavirenz in people with HIV Infections as compared to genotype GG.
3631	1448997712	Genotype GT is associated with increased concentrations of efavirenz in women HIV Infections as compared to genotype GG.
3630	1448997691	Genotype TT is associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotypes GG + GT.
3629	1448997679	Genotypes GT + TT are associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotype GG.
3628	1448997672	Genotype TT is associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotypes GG + GT.
3627	1448997496	Genotypes GT + TT are associated with decreased clearance of efavirenz in people with HIV Infections as compared to genotype GG.
3626	1448997489	Genotype TT is associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotypes GG + GT.
3625	1448997483	Genotypes GT + TT are associated with increased concentrations of efavirenz as compared to genotype GG.
3624	1448997462	Genotypes GT + TT are associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotype GG.
3623	1448997449	Genotype TT is associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotypes GG + GT.
3622	1448997257	Genotypes GT + TT are associated with increased concentrations of efavirenz in children with HIV Infections as compared to genotype GG.
3621	1448997239	Genotypes GT + TT are associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotype GG.
3620	1448997232	Genotypes GT + TT are associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotype GG.
3619	1448997225	Genotypes GT + TT are associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotype GG.
3618	1448997218	Genotypes GT + TT is associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotype GG.
3617	1448997209	Genotypes GT + TT are associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotype GG.
3616	1448997148	Genotype TT are associated with decreased clearance of efavirenz in people with HIV Infections as compared to genotype GG.
3615	1448997129	Genotypes GT + TT are associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotype GG.
3614	1448997108	Genotypes GT + TT are associated with increased concentrations of efavirenz in children with HIV Infections as compared to genotype GG.
3613	1448995941	Genotype TT is associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotypes GG + GT.
3612	1448995933	Genotype TT is associated with increased concentrations of efavirenz in people with HIV Infections and Tuberculosis as compared to genotypes GG + GT.
3611	1448994415	Genotype TT is associated with increased concentrations of efavirenz in children with HIV Infections.
3610	1448994222	Genotypes GT + TT are associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotype GG.
3609	1448993700	Genotype TT is associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotypes GG + GT.
3608	1448993691	Genotypes GT + TT are associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotype GG.
3607	1448993476	Genotype TT is associated with increased concentrations of efavirenz in people with HIV Infections and Tuberculosis as compared to genotypes GG + GT.
3606	1448821568	Genotypes GT + TT is associated with increased concentrations of efavirenz in children with HIV Infections as compared to genotype GG.
3605	1448684688	Genotypes GT + TT are associated with increased concentrations of efavirenz in women with HIV Infections as compared to genotype GG.
3604	1448663995	Genotypes GT + TT are associated with increased concentrations of efavirenz in children with HIV Infections as compared to genotype GG.
3603	1448636173	Genotypes GT + TT is associated with decreased clearance of efavirenz in people with HIV Infections as compared to genotype GG.
3602	1448633511	Genotypes GT + TT are associated with increased concentrations of efavirenz in people with HIV Infections as compared to genotype GG.
3601	1448265859	Allele T is associated with increased concentrations of efavirenz in people with HIV Infections as compared to allele G.
3600	1444698851	Allele T is associated with decreased clearance of efavirenz in people with HIV Infections as compared to allele G.
3599	1451131980	Genotype TT is associated with decreased metabolism of efavirenz in women with HIV Infections as compared to genotype GG.
3598	1451127146	Genotypes GT + TT are associated with increased exposure to efavirenz in healthy individuals as compared to genotype GG.
3597	1451122240	Allele T is associated with increased concentrations of efavirenz in women HIV Infections and Malaria as compared to genotype GG.
3596	1185234900	Genotypes GT + TT is associated with concentrations of efavirenz in people with HIV Infections as compared to genotype GG.
3595	1184988306	Allele T is associated with decreased metabolism of efavirenz in people with HIV Infections.
3594	1184988061	Genotype TT is associated with decreased metabolism of efavirenz in people with HIV Infections and Tuberculosis as compared to genotypes GG + GT.
3593	1184987905	Genotype TT is associated with decreased dose of efavirenz in people with HIV Infections.
3592	1184512470	Genotype TT is associated with decreased clearance of efavirenz in children with HIV Infections as compared to genotype GG.
3591	1184511673	Genotype TT is associated with decreased dose of efavirenz in men with HIV Infections.
3590	1184473321	Allele T is associated with decreased metabolism of efavirenz in people with HIV Infections.
3589	1184473309	Genotype TT is associated with decreased metabolism of efavirenz in people with HIV Infections as compared to genotype GG.
3588	1184473245	Genotype GT is associated with decreased metabolism of efavirenz in people with HIV Infections as compared to genotype GG.
3587	1184473241	Genotype TT is associated with decreased metabolism of efavirenz in people with HIV Infections as compared to genotype GT.
3586	1184473237	Genotype TT is associated with decreased metabolism of efavirenz in people with HIV Infections as compared to genotype GG.
3585	1184473161	Allele T is associated with metabolism of efavirenz in people with HIV Infections as compared to allele G.
3584	1184473123	Genotype GT is associated with decreased metabolism of efavirenz in people with HIV Infections as compared to genotype GG.
3583	1184473116	Genotype TT is associated with decreased metabolism of efavirenz in people with HIV Infections as compared to genotype GG.
3582	1184472014	Genotype TT is associated with decreased clearance of efavirenz in people with HIV Infections as compared to genotype GT.
3581	1184471369	Allele T (assigned as poor metabolizer phenotype) is associated with decreased metabolism of efavirenz in people with HIV Infections as compared to allele G (assigned as normal metabolizer phenotype) .
3580	1184471312	Genotype TT (assigned as poor metabolizer phenotype) is associated with decreased metabolism of efavirenz in people with HIV Infections as compared to genotype GG (assigned as normal metabolizer phenotype) .
3579	1184349348	Genotypes GT + TT is associated with decreased metabolism of efavirenz in people with HIV Infections as compared to genotype GG.
3578	1184233832	Genotype GT is associated with decreased clearance of efavirenz in people with HIV Infections as compared to genotype GG.
3577	1184233697	Genotype TT is associated with decreased clearance of efavirenz in children with HIV Infections.
3576	1183634159	Genotype TT is associated with increased plasma concentration of efavirenz in people with HIV Infections as compared to genotypes GG + GT.
3575	1183634127	Genotype GT is associated with increased plasma level of efavirenz in people with HIV Infections as compared to genotype GG.
3574	1183491421	Genotype GT is associated with decreased clearance of efavirenz in people with HIV Infections as compared to genotype GG.
3573	1183491417	Genotype TT is associated with decreased clearance of efavirenz in people with HIV Infections as compared to genotype GT.
3572	1183491412	Genotype TT is associated with decreased clearance of efavirenz in people with HIV Infections as compared to genotype GG.
3571	769162974	Genotype TT is associated with increased intracellular PBMC exposure of efavirenz in people with HIV Infections as compared to genotype GG.
3570	769163086	Genotype TT is associated with increased plasma concentration (p<0.001) of efavirenz in people with HIV Infections as compared to genotypes GG + GT.
3569	769163473	Genotype TT is associated with increased mid-dose plasma concentrations of efavirenz in people with HIV Infections as compared to genotypes GG + GT.
3568	769163543	Genotype TT is associated with increased plasma exposure of efavirenz in people with HIV Infections as compared to genotype GG.
3567	769162981	Genotypes GT + TT are associated with increased PBMC-associated drug concentrations of efavirenz in people with HIV Infections as compared to genotype GG.
3566	827922951	Allele T is associated with increased plasma efavirenz exposure (AUC) during the first 24 weeks of antiretroviral therapy when treated with efavirenz in people with HIV Infections as compared to allele G.
3565	827811199	Genotype TT is associated with increased plasma concentration of efavirenz in people with HIV Infections as compared to genotypes GG + GT.
3564	827807674	Allele T is associated with increased plasma concentration of efavirenz in people with HIV Infections as compared to allele G.
3563	827695744	Genotype TT is associated with increased plasma exposure of efavirenz in people with HIV Infections as compared to genotype GG.
3562	827692937	Genotype TT is associated with increased minimum plasma concentrations of efavirenz in people with HIV Infections as compared to genotype GG.
3561	982046514	Allele T is associated with increased plasma Cmin values when treated with efavirenz in HIV Infections as compared to allele G.

临床病史

id	类型	评论
598	Update	CA score added as part of scoring system release. LOE assigned following curator review.
597	Update	updated text
596	Note	Double checked.
595	Update	changed to PK
594	Update	Added PMIDs 24831655 and 31628422 to evidence
593	Update	upgrade to level 1A based on CPIC efavirenz guideline
592	Update	Added PMID 29624706

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