阿托伐他汀,临床注释-2,变异和临床注释数据

阿托伐他汀

临床注释ID

1043880818

药物名称(英)

atorvastatin

变异单倍型

rs4149056

基因

SLCO1B1

证据级别

1A

水平覆盖

水平修饰符

Tier 1 VIP

表现型类别(英)

Toxicity

表现型类别

毒性

分数

207.25

PMID计数

17

计数的证据

19

表现型

他汀类药物相关性肌病

表现型(英)

statin-related myopathy

最新日期

2022/2/15 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/1043880818

专业人口(英)

专业人口

临床等位基因

id	等位基因	注释文本
1207	TT	Patients with the rs4149056 TT genotype may have a decreased risk of myopathy when treated with atorvastatin as compared to patients with the CC or CT genotypes. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of developing myopathy when treated with atorvastatin.
1206	CT	Patients with the rs4149056 CT genotype may have an increased risk of myopathy when treated with atorvastatin as compared to patients with the TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of developing myopathy when treated with atorvastatin.
1205	CC	Patients with the rs4149056 CC genotype may have an increased risk of myopathy when treated with atorvastatin as compared to patients with the TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of developing myopathy when treated with atorvastatin.

临床证据

id	证据的ID	总结
4175	1184989268	SLCO1B1 5 is associated with increased risk of Drug Toxicity when treated with atorvastatin, pravastatin or simvastatin in people with Hypercholesterolemia as compared to SLCO1B1 1.
4174	1449576945	Genotypes CC + CT are associated with increased likelihood of statin-related myopathy when treated with atorvastatin or simvastatin as compared to genotype TT.
4173	1448613086	Allele C is not associated with increased risk of Muscular Diseases when treated with atorvastatin, fluvastatin, hmg coa reductase inhibitors, pitavastatin, pravastatin, rosuvastatin or simvastatin as compared to allele T.
4172	1447689782	Genotypes CC + CT is associated with increased likelihood of Drug Toxicity, Muscular Diseases, Rhabdomyolysis and Toxic liver disease when treated with atorvastatin as compared to genotype TT.
4171	1183699594	Genotypes CC + CT are associated with increased risk of dose decrease or switch to another cholesterol-lowering drug in users with a starting dose of more than 20 mg when treated with atorvastatin as compared to genotype TT.
4170	1183689645	Allele C is associated with all statin-induced myopathy and severe myopathy when treated with atorvastatin, fluvastatin, hmg coa reductase inhibitors, pravastatin, rosuvastatin or simvastatin as compared to allele T.
4169	769164520	Allele C is not associated with risk of Muscular Diseases when treated with atorvastatin in people with Hyperlipidemias as compared to allele T.
4168	827810986	Genotypes CC + CT are not associated with increased risk of Myalgia unspecified when treated with atorvastatin in people with Hypercholesterolemia as compared to genotype TT.
4167	1451480162	Genotypes CC + CT are not associated with increased risk of statin-related myopathy when treated with atorvastatin as compared to genotype TT.
4166	1451479880	Genotypes CC + CT are associated with increased risk of statin-related myopathy when treated with atorvastatin as compared to genotype TT.
4165	1451465304	Genotype CC is not associated with increased risk of statin-related myopathy when treated with atorvastatin as compared to genotype TT.
4164	1451390500	Genotypes CC + CT are associated with increased risk of statin-related myopathy when treated with atorvastatin as compared to genotype TT.
4163	1451390498	Genotypes CC + CT are not associated with increased risk of statin-related myopathy when treated with atorvastatin as compared to genotype TT.
4162	1448821136	Allele C is not associated with likelihood of statin-related myopathy when treated with atorvastatin or simvastatin in people with Coronary Artery Disease as compared to allele T.
4161	1451226140	Genotype TT is not associated with increased likelihood of Muscular Diseases when treated with atorvastatin or rosuvastatin in people with Diabetes Mellitus, Hyperlipidemias, Hypertension or Obesity as compared to genotypes CC + CT.
4160	1451163185	Allele C is associated with increased risk of Muscular Diseases when treated with atorvastatin.
4159	1451151642	Allele C is not associated with risk of statin-related myopathy due to atorvastatin as compared to allele T.
4158	PA166182843	Annotation of DPWG Guideline for atorvastatin and SLCO1B1
4157	PA166262221	Annotation of CPIC Guideline for atorvastatin and SLCO1B1

临床病史

id	类型	评论
591	Note	Second curator check
590	Update	added guideline as evidence
589	Update	updated text
588	Update	CA score added as part of scoring system release. LOE assigned following curator review.
587	Update	added guideline as evidence, updated text
586	Update	Edited this CA to be on toxicity only. PK VAs have been moved to a new CA. Added PMIDs 23942138, 24263182, 26086347, 27839692, 28812116, 28940218, 32453264, 32128760 and 30595243 to evidence. Edited phenotype descriptions.
585	Update
584	Update	2/26/16: Added more descriptive annotation types instead of 'other'.

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