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辛伐他汀；辛伐他汀酸
临床注释ID
1451681540
药物名称(英)
simvastatin;simvastatin acid
变异单倍型
SLCO1B1*1, SLCO1B1*5, SLCO1B1*15
基因
SLCO1B1
证据级别
1A
水平覆盖
水平修饰符
Tier 1 VIP
表现型类别(英)
Metabolism/PK
表现型类别
代谢/PK
分数
110.625
PMID计数
9
计数的证据
10
表现型
表现型(英)
最新日期
2022/2/14 0:00:00
URL
https://www.pharmgkb.org/clinicalAnnotation/1451681540
专业人口(英)
Pediatric
专业人口
儿科
临床等位基因
id等位基因注释文本
1189 *15 The SLCO1B1*15 allele (defined as consisting of both rs4149056 and rs2306283) is assigned as a no function allele by CPIC. Patients carrying SLCO1B1*15 allele in combination with a normal, no, or increased function allele may have increased simvastatin acid concentration when treated with simvastatin as compared to patients with two normal function alleles. Other genetic and clinical factors may also influence the metabolism of simvastatin. This annotation only covers the pharmacokinetic relationship between SLCO1B1 and simvastatin acid or simvastatin and does not include evidence about clinical outcomes.
1188 *5 The SLCO1B1*5 allele (defined as consisting of rs4149056) is assigned as a no function allele by CPIC. Patients carrying SLCO1B1*5 allele in combination with a normal, no, or increased function allele may have increased simvastatin acid concentration when treated with simvastatin as compared to patients with two normal function alleles. Other genetic and clinical factors may also influence the metabolism of simvastatin. This annotation only covers the pharmacokinetic relationship between SLCO1B1 and simvastatin acid or simvastatin and does not include evidence about clinical outcomes.
1187 *1 The SLCO1B1*1 allele is assigned as a normal function allele by CPIC. Patients carrying SLCO1B1*1 allele in combination with another normal function allele may have decreased simvastatin acid concentration when treated with simvastatin as compared to patients with a no function allele in combination with a normal or increased function allele or with two no function alleles. Other genetic and clinical factors may also influence the metabolism of simvastatin. This annotation only covers the pharmacokinetic relationship between SLCO1B1 and simvastatin acid or simvastatin and does not include evidence about clinical outcomes.
临床证据
id证据的ID总结
4121 1449556752 Genotypes CC + CT are associated with increased concentrations of simvastatin acid in children as compared to genotype TT.
4120 1448612369 Genotype CT is associated with increased exposure to simvastatin acid as compared to genotype TT.
4119 1446907580 Allele C is associated with increased concentrations of simvastatin acid in healthy individuals as compared to genotype TT.
4118 1451352500 Genotype CT is associated with increased exposure to simvastatin acid in healthy individuals as compared to genotype TT.
4117 1451352480 Genotype CT is associated with increased concentrations of simvastatin acid in healthy individuals as compared to genotype TT.
4116 1447983120 Genotype CC is associated with increased concentrations of simvastatin acid in healthy individuals as compared to genotype TT.
4115 1184754854 Genotype CT is associated with decreased clearance of simvastatin acid as compared to genotype TT.
4114 1451249860 Genotype CC is associated with increased concentrations of simvastatin acid in healthy individuals as compared to genotypes CT + TT.
4113 1446896983 Allele C is associated with increased concentrations of simvastatin and simvastatin acid in people with Hypercholesterolemia as compared to allele T.
4112 PA166105005 Annotation of CPIC Guideline for simvastatin and SLCO1B1
临床病史
id类型评论
569 Create Created
568 Note Second curator check

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