id	等位基因	注释文本
1186	TT	Patients with the rs4149056 TT genotype may have a lower risk of simvastatin-related myopathy when treated with simvastatin as compared to patients with the CT or CC genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of toxicity to simvastatin.
1185	CT	Patients with the rs4149056 CT genotype may have a higher risk of simvastatin-related myopathy when treated with simvastatin as compared to patients with the TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of toxicity to simvastatin.
1184	CC	Patients with the rs4149056 CC genotype may have a higher risk of simvastatin-related myopathy when treated with simvastatin as compared to patients with the TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence risk of toxicity to simvastatin.

id	证据的ID	总结
4111	1184989268	SLCO1B1 5 is associated with increased risk of Drug Toxicity when treated with atorvastatin, pravastatin or simvastatin in people with Hypercholesterolemia as compared to SLCO1B1 1.
4110	1449576945	Genotypes CC + CT are associated with increased likelihood of statin-related myopathy when treated with atorvastatin or simvastatin as compared to genotype TT.
4109	1448613086	Allele C is not associated with increased risk of Muscular Diseases when treated with atorvastatin, fluvastatin, hmg coa reductase inhibitors, pitavastatin, pravastatin, rosuvastatin or simvastatin as compared to allele T.
4108	1183699615	Genotype CC is associated with increased risk of dose decrease or switch to another cholesterol-lowering drug when treated with simvastatin as compared to genotype TT.
4107	1183689645	Allele C is associated with all statin-induced myopathy and severe myopathy when treated with atorvastatin, fluvastatin, hmg coa reductase inhibitors, pravastatin, rosuvastatin or simvastatin as compared to allele T.
4106	769164512	Genotypes CC + CT are associated with increased risk of Muscular Diseases when treated with simvastatin in people with Hyperlipidemias as compared to genotype TT.
4105	981420028	Genotype CC is associated with increased likelihood of Muscular Diseases when treated with simvastatin in people with Myocardial Infarction as compared to genotype TT.
4104	655386692	Genotypes CC + CT are associated with increased risk of Muscular Diseases when treated with simvastatin as compared to genotype TT.
4103	1448821136	Allele C is not associated with likelihood of statin-related myopathy when treated with atorvastatin or simvastatin in people with Coronary Artery Disease as compared to allele T.
4102	1451231960	Allele C is associated with increased likelihood of Muscular Diseases when treated with simvastatin in people with Coronary Artery Disease as compared to allele T.
4101	PA166182844	Annotation of DPWG Guideline for simvastatin and SLCO1B1
4100	PA166105005	Annotation of CPIC Guideline for simvastatin and SLCO1B1

id	类型	评论
567	Note	Second curator check following addition of CPIC guideline to evidence.
566	Update	updated text
565	Update	CA score added as part of scoring system release. LOE assigned following curator review.
564	Update	added guideline as evidence, updated text
563	Update	Moved PK VAs to a different CA and removed duplicate VAs. Added PMIDs 27839692 and 28812116 to evidence. Edited phenotype descriptions
562	Update	Edited annotation text

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