id	等位基因	注释文本
1171	TT	Patients with the rs4149056 TT genotype may have decreased plasma concentrations of pravastatin as compared to patients with the CC or CT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence a patient's metabolism of pravastatin. This annotation only covers the pharmacokinetic relationship between rs4149056 and pravastatin and does not include evidence about clinical outcomes.
1170	CT	Patients with the rs4149056 CT genotype may have increased plasma concentrations of pravastatin as compared to patients with the TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence a patient's metabolism of pravastatin. This annotation only covers the pharmacokinetic relationship between rs4149056 and pravastatin and does not include evidence about clinical outcomes.
1169	CC	Patients with the rs4149056 CC genotype may have increased plasma concentrations of pravastatin as compared to patients with the TT genotype. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence a patient's metabolism of pravastatin. This annotation only covers the pharmacokinetic relationship between rs4149056 and pravastatin and does not include evidence about clinical outcomes.

id	证据的ID	总结
4507	982044004	SLCO1B1 1/15 is associated with increased pravastatin plasma concentrations (AUC) and Cmax when exposed to pravastatin in healthy individuals as compared to SLCO1B1 37/37.
4506	982043998	SLCO1B1 15/15 is associated with increased pravastatin plasma concentrations (AUC) when exposed to pravastatin in healthy individuals as compared to SLCO1B1 37/37.
4505	982043959	SLCO1B1 15/15 is associated with increased pravastatin plasma concentrations (AUC) when exposed to pravastatin in healthy individuals as compared to SLCO1B1 1/1.
4504	982043980	SLCO1B1 1/15 is associated with increased pravastatin plasma concentrations (AUC) and Cmax when exposed to pravastatin in healthy individuals as compared to SLCO1B1 1/1.
4503	1184989258	SLCO1B1 15 is associated with decreased uptake of atorvastatin, cerivastatin and pravastatin as compared to SLCO1B1 1/*1.
4502	1451451060	SLCO1B1 15 is associated with increased concentrations of pravastatin in healthy individuals as compared to SLCO1B1 1/*1.
4501	1451451080	SLCO1B1 15/15 is associated with increased concentrations of pitavastatin or pravastatin in healthy individuals as compared to SLCO1B1 1/1.
4500	827827514	SLCO1B1 15 is associated with increased relative bioavailability of pravastatin when exposed to pravastatin in healthy individuals as compared to SLCO1B1 1.
4499	769170865	Allele C is associated with decreased metabolism of pravastatin in healthy individuals as compared to allele T.
4498	827827440	Genotype CT is associated with increased pravastatin plasma concentrations (AUC) and Cmax when exposed to pravastatin in healthy individuals as compared to genotype TT.
4497	827827157	Genotype CC is associated with increased mean peak concentration in plasma and area under the plasma concentration when exposed to pravastatin in men as compared to genotypes CT + TT.
4496	827827131	Allele C is associated with increased pravastatin plasma concentrations (AUC) and Cmax when exposed to pravastatin as compared to allele T.
4495	827826991	Allele C is associated with increased pravastatin plasma concentrations (AUC) when exposed to pravastatin in healthy individuals as compared to allele T.
4494	982043158	Genotype CT is associated with increased metabolism of pravastatin in children with Transplantation as compared to genotype TT.
4493	982043146	Genotype CT is not associated with increased metabolism of pravastatin in children with Hyperlipoproteinemia Type II as compared to genotype TT.
4492	982042588	Genotype CT is associated with increased AUC0-12 when exposed to pravastatin in healthy individuals as compared to genotype TT.
4491	1451451120	Allele C is associated with decreased clearance of pravastatin in healthy individuals as compared to allele T.
4490	1451226263	Genotypes CC + CT are associated with increased concentrations of pravastatin in children with Hypercholesterolemia as compared to genotype TT.
4489	PA166262281	Annotation of CPIC Guideline for pravastatin and SLCO1B1

id	类型	评论
1666	Note	Second curator check
1665	Update	added guideline as evidence
1664	Update	CA score added as part of scoring system release. LOE may have automatically changed based on new score but may be subject to further changes upon curator review.
1663	Update	Added PMIDs 17015053 and 30549267 to evidence and edited phenotype descriptions. Marked conflicting VA.
1662	Update

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