聚乙二醇干扰素 alfa-2a；聚乙二醇干扰素 alfa-2b；利巴韦林,临床注释-2,变异和临床注释数据

聚乙二醇干扰素 alfa-2a；聚乙二醇干扰素 alfa-2b；利巴韦林

临床注释ID

1448102439

药物名称(英)

peginterferon alfa-2a;peginterferon alfa-2b;ribavirin

变异单倍型

rs11881222

基因

IFNL3

证据级别

水平覆盖

水平修饰符

表现型类别(英)

Efficacy

表现型类别

功效

分数

11.5

PMID计数

计数的证据

表现型

丙型肝炎；艾滋病毒感染

表现型(英)

Hepatitis C;HIV Infections

最新日期

2021/3/24 0:00:00

URL

https://www.pharmgkb.org/clinicalAnnotation/1448102439

专业人口(英)

专业人口

临床等位基因

id	等位基因	注释文本
1159	GG	Patients with the rs11881222 GG genotype and hepatitis C or HIV may have a poorer response to treatment with peginterferon-alpha and ribavirin as compared to patients with the AA genotype. Other genetic and clinical factors may also influence response to peginterferon-alpha and ribavirin treatment.
1158	AG	Patients with the rs11881222 AG genotype and hepatitis C or HIV may have a poorer response to treatment with peginterferon-alpha and ribavirin as compared to patients with the AA genotype. Other genetic and clinical factors may also influence response to peginterferon-alpha and ribavirin treatment.
1157	AA	Patients with the rs11881222 AA genotype and hepatitis C or HIV may have a better response to treatment with peginterferon-alpha and ribavirin as compared to patients with the AG or GG genotype. Other genetic and clinical factors may also influence response to peginterferon-alpha and ribavirin treatment.

临床证据

id	证据的ID	总结
4475	1444843596	Genotype AA is associated with increased response to peginterferon alfa-2a, peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotype AG.
4474	1444705502	Genotypes AG + GG is associated with decreased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C, Chronic as compared to genotype AA.
4473	1444705070	Genotype AA is associated with increased response to peginterferon alfa-2b and ribavirin in people with Hepatitis C and HIV Infections as compared to genotypes AG + GG.
4472	981477593	Allele G is associated with increased response to peginterferon alfa-2a and ribavirin in people with Hepatitis C, Chronic as compared to allele A.

临床病史

id	类型	评论
1655	Update	CA score added as part of scoring system release. LOE assigned following curator review.
1654	Create

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