卡马西平
临床注释ID
1183701224
药物名称(英)
carbamazepine
变异单倍型
HLA-A*31:01:02
基因
HLA-A
证据级别
1A
水平覆盖
水平修饰符
表现型类别(英)
Toxicity
表现型类别
毒性
分数
142.875
PMID计数
16
计数的证据
28
表现型
药物超敏反应;嗜酸性粒细胞增多和全身症状的药物反应;表皮坏死松解症,毒性;斑丘疹;史蒂文斯-约翰逊综合征
表现型(英)
Drug Hypersensitivity;drug reaction with eosinophilia and systemic symptoms;Epidermal Necrolysis, Toxic;Maculopapular Exanthema;Stevens-Johnson Syndrome
最新日期
2021/3/24 0:00:00
URL
https://www.pharmgkb.org/clinicalAnnotation/1183701224
专业人口(英)
Pediatric
专业人口
儿科
临床证据
id证据的ID总结
2301 1450376262 HLA-A *31:01:02 is associated with increased risk of Maculopapular Exanthema due to carbamazepine.
2300 1450376254 HLA-A *31:01:02 is not associated with risk of Maculopapular Exanthema due to carbamazepine.
2299 1449295707 HLA-A *31:01:02 is associated with increased risk of drug reaction with eosinophilia and systemic symptoms, Erythema multiforme NOS, Hypersensitivity and Maculopapular Exanthema when treated with carbamazepine in people with Bipolar Disorder, Epilepsy, Neuralgia or Schizophrenia.
2298 1448612304 HLA-A *31:01:02 is associated with Exanthema when treated with carbamazepine in people with Epilepsy.
2297 1448525723 HLA-A *31:01:02 is associated with increased risk of drug reaction with eosinophilia and systemic symptoms when treated with carbamazepine.
2296 1444935634 HLA-A *31:01:02 is associated with increased risk of Maculopapular Exanthema when treated with carbamazepine.
2295 1296598666 HLA-A *31:01:02 is associated with increased risk of Drug Toxicity when treated with carbamazepine.
2294 1184988697 HLA-A *31:01:02 is associated with increased risk of Epidermal Necrolysis, Toxic and Stevens-Johnson Syndrome when treated with carbamazepine.
2293 1184469272 HLA-A *31:01:02 is associated with increased risk of severe cutaneous adverse reactions when treated with carbamazepine.
2292 1184469261 HLA-A *31:01:02 is associated with increased risk of drug reaction with eosinophilia and systemic symptoms when treated with carbamazepine.
2291 1184469204 HLA-A *31:01:02 is not associated with risk of severe cutaneous adverse reactions when treated with carbamazepine.
2290 1184469161 HLA-A *31:01:02 is associated with increased risk of drug reaction with eosinophilia and systemic symptoms when treated with carbamazepine.
2289 1184468448 HLA-A *31:01:02 is not associated with risk of severe cutaneous adverse reactions when treated with carbamazepine.
2288 1184468437 HLA-A *31:01:02 is associated with increased risk of Drug Hypersensitivity when treated with carbamazepine.
2287 1184468310 HLA-A *31:01:02 is not associated with risk of severe cutaneous adverse reactions when treated with carbamazepine.
2286 1184467950 HLA-A *31:01:02 is associated with increased risk of Stevens-Johnson Syndrome when treated with carbamazepine.
2285 1184467926 HLA-A *31:01:02 is associated with increased risk of severe cutaneous adverse reactions when treated with carbamazepine.
2284 1184467913 HLA-A *31:01:02 is associated with increased risk of Drug Hypersensitivity when treated with carbamazepine.
2283 1184466922 HLA-A *31:01:02 is associated with increased risk of severe cutaneous adverse reactions when treated with carbamazepine.
2282 1184466916 HLA-A *31:01:02 is associated with increased risk of Maculopapular Exanthema when treated with carbamazepine.
2281 1184466909 HLA-A *31:01:02 is associated with increased risk of Drug Hypersensitivity when treated with carbamazepine.
2280 1184466701 HLA-A *31:01:02 is associated with increased risk of severe cutaneous adverse reactions when treated with carbamazepine.
2279 1183702064 HLA-A *31:01:02 is associated with increased risk of severe cutaneous adverse reactions when treated with carbamazepine.
2278 993944301 HLA-A *31:01:02 is not associated with increased risk of Stevens-Johnson Syndrome when treated with carbamazepine in children.
2277 993813998 HLA-A *31:01:02 is associated with increased risk of Maculopapular Exanthema when treated with carbamazepine in children.
2276 992282434 HLA-A *31:01:02 is associated with increased risk of Carbamazepine-induced hypersensitivity syndrome when treated with carbamazepine in children.
2275 981482109 HLA-A *31:01:02 is associated with increased risk of carbamazepine-induced hypersensitivity when treated with carbamazepine.
2274 PA166105008 Annotation of CPIC Guideline for carbamazepine and HLA-A, HLA-B
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