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当前位置:药药网 / 数据中心 / 临床注释-2,变异和临床注释数据
卡马西平
临床注释ID
1183701224
药物名称(英)
carbamazepine
变异单倍型
HLA-A*31:01:02
基因
HLA-A
证据级别
1A
水平覆盖
水平修饰符
表现型类别(英)
Toxicity
表现型类别
毒性
分数
142.875
PMID计数
16
计数的证据
28
表现型
药物超敏反应;嗜酸性粒细胞增多和全身症状的药物反应;表皮坏死松解症,毒性;斑丘疹;史蒂文斯-约翰逊综合征
表现型(英)
Drug Hypersensitivity;drug reaction with eosinophilia and systemic symptoms;Epidermal Necrolysis, Toxic;Maculopapular Exanthema;Stevens-Johnson Syndrome
最新日期
2021/3/24 0:00:00
URL
https://www.pharmgkb.org/clinicalAnnotation/1183701224
专业人口(英)
Pediatric
专业人口
儿科
临床等位基因
id
等位基因
注释文本
799
*31:01:02
Patients with one or two copies of the HLA-A*31:01:02 allele who are treated with carbamazepine may have an increased risk of severe cutaneous adverse reactions as compared to patients with no HLA-A*31:01:02 alleles or negative for the HLA-A*31:01:02 test. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence a patient's risk of adverse reactions.
临床证据
id
证据的ID
总结
2301
1450376262
HLA-A *31:01:02 is associated with increased risk of Maculopapular Exanthema due to carbamazepine.
2300
1450376254
HLA-A *31:01:02 is not associated with risk of Maculopapular Exanthema due to carbamazepine.
2299
1449295707
HLA-A *31:01:02 is associated with increased risk of drug reaction with eosinophilia and systemic symptoms, Erythema multiforme NOS, Hypersensitivity and Maculopapular Exanthema when treated with carbamazepine in people with Bipolar Disorder, Epilepsy, Neuralgia or Schizophrenia.
2298
1448612304
HLA-A *31:01:02 is associated with Exanthema when treated with carbamazepine in people with Epilepsy.
2297
1448525723
HLA-A *31:01:02 is associated with increased risk of drug reaction with eosinophilia and systemic symptoms when treated with carbamazepine.
2296
1444935634
HLA-A *31:01:02 is associated with increased risk of Maculopapular Exanthema when treated with carbamazepine.
2295
1296598666
HLA-A *31:01:02 is associated with increased risk of Drug Toxicity when treated with carbamazepine.
2294
1184988697
HLA-A *31:01:02 is associated with increased risk of Epidermal Necrolysis, Toxic and Stevens-Johnson Syndrome when treated with carbamazepine.
2293
1184469272
HLA-A *31:01:02 is associated with increased risk of severe cutaneous adverse reactions when treated with carbamazepine.
2292
1184469261
HLA-A *31:01:02 is associated with increased risk of drug reaction with eosinophilia and systemic symptoms when treated with carbamazepine.
2291
1184469204
HLA-A *31:01:02 is not associated with risk of severe cutaneous adverse reactions when treated with carbamazepine.
2290
1184469161
HLA-A *31:01:02 is associated with increased risk of drug reaction with eosinophilia and systemic symptoms when treated with carbamazepine.
2289
1184468448
HLA-A *31:01:02 is not associated with risk of severe cutaneous adverse reactions when treated with carbamazepine.
2288
1184468437
HLA-A *31:01:02 is associated with increased risk of Drug Hypersensitivity when treated with carbamazepine.
2287
1184468310
HLA-A *31:01:02 is not associated with risk of severe cutaneous adverse reactions when treated with carbamazepine.
2286
1184467950
HLA-A *31:01:02 is associated with increased risk of Stevens-Johnson Syndrome when treated with carbamazepine.
2285
1184467926
HLA-A *31:01:02 is associated with increased risk of severe cutaneous adverse reactions when treated with carbamazepine.
2284
1184467913
HLA-A *31:01:02 is associated with increased risk of Drug Hypersensitivity when treated with carbamazepine.
2283
1184466922
HLA-A *31:01:02 is associated with increased risk of severe cutaneous adverse reactions when treated with carbamazepine.
2282
1184466916
HLA-A *31:01:02 is associated with increased risk of Maculopapular Exanthema when treated with carbamazepine.
2281
1184466909
HLA-A *31:01:02 is associated with increased risk of Drug Hypersensitivity when treated with carbamazepine.
2280
1184466701
HLA-A *31:01:02 is associated with increased risk of severe cutaneous adverse reactions when treated with carbamazepine.
2279
1183702064
HLA-A *31:01:02 is associated with increased risk of severe cutaneous adverse reactions when treated with carbamazepine.
2278
993944301
HLA-A *31:01:02 is not associated with increased risk of Stevens-Johnson Syndrome when treated with carbamazepine in children.
2277
993813998
HLA-A *31:01:02 is associated with increased risk of Maculopapular Exanthema when treated with carbamazepine in children.
2276
992282434
HLA-A *31:01:02 is associated with increased risk of Carbamazepine-induced hypersensitivity syndrome when treated with carbamazepine in children.
2275
981482109
HLA-A *31:01:02 is associated with increased risk of carbamazepine-induced hypersensitivity when treated with carbamazepine.
2274
PA166105008
Annotation of CPIC Guideline for carbamazepine and HLA-A, HLA-B
临床病史
id
类型
评论
1187
Update
CA score added as part of scoring system release. LOE assigned following curator review.
1186
Update
Attached CPIC guideline and removed override. Added conflicting evidence statement.
1185
Update
Added sentence about some no association studies.
1184
Update
Level 1A because of score and guideline.
1183
Update
Added PMID 29288229 to evidence
1182
Update
Added PMID 29610831
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