总结
CYP2A6 *1A/*2 + *1A/*4A + *1A/*9 + *1A/*12 + *1A/*17 + *1A/*20 + *1A/*23 + *1A/*24A + *1A/*25 + *1A/*26 + *1A/*27 + *1A/*28A + *1A/*35 + *9/*9 + *17/*17 + *20/*20 + *35/*35 (assigned as intermediate and low activity phenotype) are associated with decreased metabolism of nicotine as compared to CYP2A6 *1A/*1A +*1A/*46 + *46/*46 (assigned as normal metabolizer phenotype) .