Variant Phenotype Annotation
证据URL
https://www.pharmgkb.org/variantAnnotation/1183624218
总结
CYP2D6 *1/*4 + *1/*5 is associated with decreased concentrations of 10-OH-nortriptyline and higher nortriptyline/10-OH-nortriptyline ratio when treated with nortriptyline in people with Depressive Disorder, Major as compared to CYP2D6 *1/*1.