Variant Phenotype Annotation
证据URL
https://www.pharmgkb.org/variantAnnotation/1351431664
总结
TPMT *1/*2 + *1/*3A + *1/*3C + *1/*9 + *1/*21 + *1/*33 + *1/*34 are associated with increased risk of Neutropenia and Thrombocytopenia when treated with mercaptopurine or thioguanine in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to TPMT *1/*1.