Variant Phenotype Annotation
证据URL
https://www.pharmgkb.org/variantAnnotation/1444713116
总结
CYP2D6 *3/*4 + *3/*5 + *3/*6 + *4/*4 + *4/*5 + *4/*6 + *6/*7 (assigned as poor metabolizers phenotype) are associated with decreased Recurrence free survival when treated with tamoxifen in women with Breast Neoplasms as compared to CYP2D6 *1/*1 + *1/*2 + *1/*35 + *2/*2 + *2/*35 + *35/*35 (assigned as normal metabolizers phenotype) .