Variant Phenotype Annotation
证据URL
https://www.pharmgkb.org/variantAnnotation/1447959040
总结
Allele C is not associated with Drug Toxicity when treated with capecitabine or fluorouracil in people with Neoplasms.
得分
This annotation is not used for clinical annotation scoring. Article designed about c.1129鈥?923C>G as additional risk variant and not to detect association with toxicity and c.1679T>G In the conclusion the authors state: "....c.1129鈥?923C>G DPYD variant as a predictive marker of early鈥恛nset FP toxicity in a 鈥渞eal鈥恮orld鈥?clinical setting. We estimate that fewer than 50 patients need to be screened prior to therapy for this variant and for c.1905+1G>A, c.1679T>G and c.2846A>T in order to prevent one case of severe FP toxicity."