Variant Drug Annotation
证据URL
https://www.pharmgkb.org/variantAnnotation/1183697486
总结
CYP2D6 *1/*1 + *1/*10 (assigned as normal metabolizer phenotype) are associated with decreased metabolism of aripiprazole in healthy individuals also being given paroxetine as compared to CYP2D6 *10/*10 + *10/*21 (assigned as intermediate metabolizer phenotype) .
得分
This annotation is not used for clinical annotation scoring. Paroxetine is a strong CYP2D6 inhibitor