Variant Drug Annotation
证据URL
https://www.pharmgkb.org/variantAnnotation/1451161540
总结
CYP2D6 *1/*2xN + *2/*2xN (assigned as ultrarapid metabolizer phenotype) are associated with increased concentrations of methadone in people with Opioid-Related Disorders as compared to CYP2D6 normal metabolizer genotype.
得分
This annotation is not used for clinical annotation scoring. UMs had significantly higher doses of methadone compared to other phenotype groups