The CYP2D6*17 allele is assigned as a decreased function allele with an activity value of 0.5 by CPIC. Patients carrying the *17 allele in combination with a decreased or no function allele may have a decreased analgesic response when treated with tramadol as compared to patients with alleles that result in a normal metabolizer phenotype, while patients carrying the *17 allele in combination with an increased function allele may have an increased analgesic response when treated with tramadol as compared to patients with alleles that result in a normal metabolizer phenotype. Other genetic and clinical factors may also influence analgesic response when treated with tramadol.
等位基因的功能
Decreased function