Infants with the rs1799971 GG genotype may be less likely to require treatment with morphine for neonatal abstinence syndrome as compared to infants with the AA genotype. This drug-variant pair has been assigned a 鈥渘o recommendation鈥?by CPIC, as it was determined to be not clinically actionable. Other genetic and clinical factors may also affect severity of neonatal abstinence syndrome.