Patients with the TT genotype may have decreased metabolism of naproxen as compared to patients with the AA genotype. This drug-variant pair has been assigned a 鈥渘o recommendation鈥?by CPIC, as it was determined to be not clinically actionable. Other genetic and clinical factors may also affect naproxen metabolism. This annotation only covers the pharmacokinetic relationship between rs780801862 and naproxen and does not include evidence about clinical outcomes.