Infants with the rs1799971 AA genotype may be more likely to require treatment with morphine for neonatal abstinence syndrome as compared to infants with the AG or GG genotypes. This drug-variant pair has been assigned a 鈥渘o recommendation鈥?by CPIC, as it was determined to be not clinically actionable. Other genetic and clinical factors may also affect severity of neonatal abstinence syndrome.