The UGT1A1*28 allele has been assigned as a decreased function allele by CPIC. Patients carrying the UGT1A1*28 allele in combination with a normal function allele may have increased likelihood of neutropenia when treated with irinotecan-based regimens as compared to patients with two normal function alleles but decreased likelihood of neutropenia compared to patients with two decreased function alleles. However, conflicting evidence has been reported. Other genetic and clinical factors may also influence irinotecan related neutropenia.
等位基因的功能
Decreased function